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About Acetylacetonates

Acetylacetone Formula Diagram (C5H8O2)

Acetylacetonates are coordination complexes derived from acetylacetone and metal salts, most often salts of transition metals. These compounds allow many metal ions to be soluble in organic solvent, in contrast to most metal salts. This allows them to be used as catalyst precursors and reagents in reactions which occur in organic phase in chemical synthesis.

Acetylacetonates are frequently used as shift reagents in nuclear magnetic resonance (NMR) spectroscopy, a research and analysis technique that exploits magnetic properties of atomic nuclei to provide detailed information about a chemical substance. Additionally, some acetylacetonates can be used as precursors for deposition of thin films using metal organic chemical vapour deposition (MOCVD) or atomic layer epitaxy (ALE). Aluminum acetylacetonate has been used in MOCVD way to deposit films of crystalline aluminum oxide, while ALE can be used to deposit gallium oxide from gallium acetylactetonate. The latter compound can also be used as a precursor to catalytic growth of gallium nitride nanostructures.

Acetylacetonate Products

American Elements manufactures multiple forms of acetylacetonate compounds including solutions, nanopowders, submicron, and -325 mesh powders, and high surface area materials with particle distribution and particle size controlled and certified. We also produce larger -40 mesh, -100 mesh, -200 mesh range sizes and <0.5 mm, 2 mm, 5 mm and other sizes of shot, granules, lump, flake and pieces. Purities include 99%, 99.9%, 99.99%, 99.999% and 99.9999% (2N, 3N, 4N, 5N and 6N).

American Elements maintains industrial scale production for all its acetylacetonates products and will execute Non-Disclosure or Confidentiality Agreements to protect customer know-how.

Recent Research & Development for Acetylacetonates

  • An oxygen-chelate complex, palladium bis-acetylacetonate, induces apoptosis in H460 cells via endoplasmic reticulum stress pathway rather than interacting with DNA. Wang Y, Hu J, Cai Y, Xu S, Weng B, Peng K, Wei X, Wei T, Zhou H, Li X, Liang G. J Med Chem. 2013 Dec 12
  • Enhancing the Deperoxidation Activity of Cobalt(II)Acetylacetonate by the Addition of Octanoic Acid. Spier E, Hermans I. Chemphyschem. 2013 Jul 24.
  • Single-molecule magnetism in three related {Co(III)2Dy(III)2}-acetylacetonate complexes with multiple relaxation mechanisms. Langley SK, Chilton NF, Moubaraki B, Murray KS. Inorg Chem. 2013 Jun 17
  • [Differentiated fluorescence centers in europium acetylacetonate hydrate doped poly methyl methacrylate]. Zhang YY, Zhong H, Chen BJ, Xia Y, Lin H. Guang Pu Xue Yu Guang Pu Fen Xi. 2014 Jun
  • Synthesis, characterization and cell viability test of six vanadyl complexes with acetylacetonate derivatives. Sgarbossa S, Diana E, Marabello D, Deagostino A, Cadamuro S, Barge A, Laurenti E, Gallicchio M, Boscaro V, Ghibaudi E. J Inorg Biochem. 2013 Nov
  • Photophysical properties of an unusual bichromophoric species constructed from a cyclometalated Pt(II) chromophore and a blue Bodipy-acetylacetonate species. Nastasi F, Puntoriero F, Serroni S, Campagna S, Olivier JH, Ziessel R. Dalton Trans. 2014 Dec 21
  • Monodentate and bridging behaviour of the sulfur-containing ligand 4'-[4-(methylsulfanyl)phenyl]-4,2':6',4''-terpyridine in two discrete zinc(II) complexes with acetylacetonate. Granifo J, Gaviño R, Freire E, Baggio R. Acta Crystallogr C. 2012 Oct
  • Photocytotoxic oxovanadium(IV) complexes of ferrocenyl-terpyridine and acetylacetonate derivatives. Balaji B, Balakrishnan B, Perumalla S, Karande AA, Chakravarty AR. Eur J Med Chem. 2015 Mar 6
  • Cyclometalated Pd(II) and Ir(III) 2-(4-bromophenyl)pyridine complexes with N-heterocyclic carbenes (NHCs) and acetylacetonate (acac): synthesis, structures, luminescent properties and application in one-pot oxidation/Suzuki coupling of aryl chlorides containing hydroxymethyl. Xu C, Li HM, Xiao ZQ, Wang ZQ, Tang SF, Ji BM, Hao XQ, Song MP. Dalton Trans. 2014 Jul 14
  • High performance polymer solar cells with as-prepared zirconium acetylacetonate film as cathode buffer layer. Tan Z, Li S, Wang F, Qian D, Lin J, Hou J, Li Y. Sci Rep. 2014 Apr 15
  • Design of layered silicate by grafting with metal acetylacetonate for high activity and chemoselectivity in photooxidation of cyclohexane. Tsunoji N, Ide Y, Yagenji Y, Sadakane M, Sano T. ACS Appl Mater Interfaces. 2014 Apr 9
  • cis-{MoO2}(2+) assisted Mannich-type addition of acetylacetonate methine to the azomethine of tridentate Schiff bases: racemic complexes with chiral transformed ligands. Kurapati SK, Pal S. Dalton Trans. 2015 Feb 7
  • Intratumoral administration of holmium-166 acetylacetonate microspheres: antitumor efficacy and feasibility of multimodality imaging in renal cancer. Bult W, Kroeze SG, Elschot M, Seevinck PR, Beekman FJ, de Jong HW, Uges DR, Kosterink JG, Luijten PR, Hennink WE, van het Schip AD, Bosch JL, Nijsen JF, Jans JJ. PLoS One. 2013
  • Vanadyl acetylacetonate upregulates PPARγ and adiponectin expression in differentiated rat adipocytes. Wu Y, Huang M, Zhao P, Yang X. J Biol Inorg Chem. 2013 Aug
  • A novel drug "copper acetylacetonate" loaded in folic acid-tagged chitosan nanoparticle for efficient cancer cell targeting. Pramanik A, Laha D, Pramanik P, Karmakar P. J Drug Target. 2014 Jan
  • Oxidatively induced P-O bond formation through reductive coupling between phosphido and acetylacetonate, 8-hydroxyquinolinate, and picolinate groups. Arias A, Forniés J, Fortuño C, Martín A, Mastrorilli P, Todisco S, Latronico M, Gallo V. Inorg Chem. 2013 May 6
  • Growth mechanisms and size control of FePt nanoparticles synthesized using Fe(CO)x (x <
  • Binary Diffusion Coefficients of Platinum(II) Acetylacetonate in Supercritical Carbon Dioxide. Kong CY, Siratori T, Wang G, Sako T, Funazukuri T. J Chem Eng Data. 2013 Nov 14
  • Effect of magnesium acetylacetonate on the signal of organic forms of vanadium in graphite furnace atomic absorption spectrometry. Kowalewska Z, Welz B, Castilho IN, Carasek E. Talanta. 2013 Jan 15
  • Antitumor efficacy and tolerability of systemically administered gallium acetylacetonate-loaded gelucire-stabilized nanoparticles. Wehrung D, Bi L, Geldenhuys WJ, Oyewumi MO. J Biomed Nanotechnol. 2013 Jun