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Gadolinium Chloride
GdCl3·6H2O
Product
Product Code
Order or Specifications
99% Gadolinium Chloride
GD-CL-01
 Contact American Elements
99.9% Gadolinium Chloride
GD-CL-03
 Contact American Elements
99.99% Gadolinium Chloride
GD-CL-04
 Contact American Elements
99.999% Gadolinium Chloride
GD-CL-05
 Contact American Elements
Gadolinium Chloride is an excellent water soluble crystalline Gadolinium source for uses compatible with chlorides. Chloride compounds can conduct electricity when fused or dissolved in water. Chloride materials can be decomposed by electrolysis to chlorine gas and the metal. They are formed through various chlorination processes whereby at least one chlorine anion (Cl-) is covalently bonded to the relevant metal or cation. Ultra high purity and proprietary formulations can be prepared. The chloride ion controls fluid equilibrium and pH levels in metabolic systems. They can form either inorganic or organic compounds. Gadolinium is utilized for both its high magnetic moment (7.94 µB) and in phosphors and scintillators. When complexed with EDTA ligands, it is used as an injectable contrast agent for patients undergoing magnetic resonance imaging. Gadolinium Chlroide is generally immediately available in most volumes. Ultra high purity and high purity compositions improve both optical quality and usefulness as scientific standards. Nanoscale (See also Nanotechnology Information and Quantum Dots) elemental powders and suspensions, as alternative high surface area forms, may be considered. We also produce Gadolinium Chloride Solution. Additional technical, research and safety (MSDS) information is available as is a Reference Calculator for converting relevant units of measurement.

Gadolinium is a Block F, Group 3, Period 6 element. The electronic configuration is [Xe]4f75d16s2. In its elemental form gadolinium's CAS number is 7440-54-2. The gadolinium atom has a radius of 178.7.pm and it's Van der Waals radius is unknown. Gadolinium is utilized for both its high magnetic moment (7.94µB) and in phosphors and scintillator material. When complexed with EDTA ligands, it is used as an injectable contrast agent for patients undergoing magnetic resonance imaging. Gadolinium is available as metal and compounds with purities from 99% to 99.999% (ACS grade to ultra-high purity); metals in the form of foil, sputtering target, and rod, and compounds as submicron and nanopowder.

Formula CAS No. Appearance Molecular Weight Density Melting Point Boiling Point Solubility Stability
GdCl3.6H2O 13450-84-5 White 263.61 2400 kg/m³     Soluble in water, moderately soluble in strong mineral acids Slightly hygroscopic
PRODUCT CATALOG Gadolinium Research, Properties, & Information Submicron & Nanopowder Tolling Ultra High Purity Sputtering Target Crystal Growth Rod, Plate, Powder, etc. MSDS
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Recent Research & Development for Gadolinium

  • Combined SPIO-gadolinium magnetic resonance imaging in cirrhotic patients: negative predictive value and role in screening for hepatocellular carcinoma. Abdom Imaging. 2007 Oct 3; [Epub ahead of print]

  • In vivo Imaging of the Systemic Recruitment of Fibroblasts to the Angiogenic Rim of Ovarian Carcinoma Tumors. Cancer Res. 2007 Oct 1;67(19):9180-9.

  • Evidence for a different anatomic basis for joint disease localization in polymyalgia rheumatica in comparison with rheumatoid arthritis. Arthritis Rheum. 2007 Sep 28;56(10):3496-3501 [Epub ahead of print]

  • Nephrogenic systemic fibrosis and gadolinium exposure: Association and lessons for idiopathic fibrosing disorders. Arthritis Rheum. 2007 Sep 28;56(10):3173-3175 [Epub ahead of print] No abstract available.

  • Cutaneous changes of nephrogenic systemic fibrosis: Predictor of early mortality and association with gadolinium exposure. Arthritis Rheum. 2007 Sep 28;56(10):3433-3441 [Epub ahead of print]

  • Gadolinium:Nonionic Contrast Media (1:1) Coronary Angiography in Patients With Impaired Renal Function. Angiology. 2007 Sep 28; [Epub ahead of print]

  • Nephrogenic systemic fibrosis (NSF): a late adverse reaction to some of the gadolinium based contrast agents. Cancer Imaging. 2007 Sep 24;7(1):130-137.

  • 3-Dimensional magnetic resonance genitography: a different look at cloacal malformations. J Urol. 2007 Oct;178(4 Pt 2):1675-8; discussion 1678-9. Epub 2007 Aug 17.

  • Spontaneous intracranial hypotension: a cause of severe acute headache. Emerg Med J. 2007 Oct;24(10):739-41.

  • Influence of Kupffer cell inactivation on cycloheximide-induced hepatic injury. Toxicology. 2007 Aug 25; [Epub ahead of print]

  • Intraosseous pilomatricoma: a possible rare skeletal manifestation of Gardner syndrome.
    Skeletal Radiol. 2007 Jan 18; [Epub ahead of print]

  • Cavernous hemangioma of the internal auditory canal.
    Eur Arch Otorhinolaryngol. 2007 Jan 18; [Epub ahead of print]

  • Nanosuspensions of alendronate with gallium or gadolinium attenuate neointimal hyperplasia in rats.
    J Control Release. 2006 Nov 11; [Epub ahead of print]

  • Receptor-mediated internalization of chelator-PNA-peptide hybridization probes for radioimaging or magnetic resonance imaging of oncogene mRNAs in tumours.
    Biochem Soc Trans. 2007 Feb;35(Pt 1):72-6.

  • Gadolinium periconceptional exposure: pregnancy and neonatal outcome.
    Acta Obstet Gynecol Scand. 2007;86(1):99-101.

  • MRI contrast agents may pose risk for patients with kidney disease.
    JAMA. 2007 Jan 17;297(3):252-3. No abstract available.

  • Clear Cell Sarcoma of Tendons and Aponeuroses: A Review.
    Arch Pathol Lab Med. 2007 Jan 1;131(1):152 [Epub ahead of print]

  • On the role of the counter-ion in defining water structure and dynamics: order, structure and dynamics in hydrophilic and hydrophobic gadolinium salt complexes.
    Dalton Trans. 2006 Dec 21;(47):5605-16. Epub 2006 Aug 25.

  • Magnetic resonance imaging findings associated with surgically proven rotator interval lesions.
    Skeletal Radiol. 2007 Jan 16; [Epub ahead of print]

  • Inflammatory synovitis due to underlying lipoma arborescens (gadolinium-enhanced MRI features): report of two cases.
    Clin Rheumatol. 2007 Jan 16; [Epub ahead of print]

 

 

Material Safety Data Sheet
  • 1 Identification of substance

    • Product details

    • Trade name Gadolinium chloride
  • 2 Composition/Data on components:

    • Chemical characterization:
                 Designation: (CAS#)                                        
      Gadolinium chloride, anhydrous (CAS# 10138-52-0), 100%
    • Identification number(s):
    • EINECS Number: 233-386-6
  • 3 Hazards identification

    • Hazard designation: Xi Irritant
    • Information pertaining to particular dangers for man and environment
      R 36/38 Irritating to eyes and skin.
  • 4 First aid measures

    • After inhalation
      Supply fresh air. If required, provide artificial respiration. Keep patient warm. Consult doctor if symptoms persist.
      Seek immediate medical advice.
    • After skin contact
      Instantly wash with water and soap and rinse thoroughly.
      Seek immediate medical advice.
    • After eye contact
      Rinse opened eye for several minutes under running water. Then consult doctor.
    • After swallowing Seek immediate medical advice.
  • 5 Fire fighting measures

    • Suitable extinguishing agents
      CO2, extinguishing powder or water jet. Fight larger fires with water jet.
    • Special hazards caused by the material, its products of combustion or
        flue gases:
      Can be released in case of fire:
      Hydrogen chloride (HCl)
    • Protective equipment:
      Wear self-contained breathing apparatus.
      Wear full protective suit.
  • 6 Accidental release measures

    • Person-related safety precautions:
      Wear protective equipment. Keep unprotected persons away.
      Ensure adequate ventilation
    • Measures for environmental protection:
      Do not allow material to be released to the environment without proper governmental permits.
    • Measures for cleaning/collecting: Collect mechanically.
    • Additional information:
      See Section 7 for information on safe handling
      See section 8 for information on personal protection equipment.
      See Section 13 for information on disposal.
  • 7 Handling and storage


    • Handling
    • Information for safe handling:
      Handle under dry protective gas.
      Keep containers tightly sealed.
      Store in cool, dry place in tightly closed containers.
      Ensure good ventilation/exhaustion at the workplace.
    • Information about protection against explosions and fires:
      No special measures required.

    • Storage
    • Requirements to be met by storerooms and containers:
      No special requirements.
    • Information about storage in one common storage facility:
      Store away from water.
      Do not store together with alkalis (caustic solutions).
    • Further information about storage conditions:
      This product is hygroscopic.
      Store under dry inert gas.
      Protect from humidity and keep away from water.
      Keep container tightly sealed.
      Store in cool, dry conditions in well sealed containers.
  • 8 Exposure controls and personal protection

    • Additional information about design of technical systems:
      Properly operating chemical fume hood designed for hazardous chemicals and having an average face velocity of at least 100 feet per minute.

    • Components with critical values that require monitoring at the
      workplace:                                                             
      Not required.
    • Additional information: No data

    • Personal protective equipment
    • General protective and hygienic measures
      The usual precautionary measures should be adhered to in handling the chemicals.
      Keep away from foodstuffs, beverages and food.
      Instantly remove any soiled and impregnated garments.
      Wash hands during breaks and at the end of the work.
      Avoid contact with the eyes and skin.
    • Breathing equipment: Use breathing protection with high concentrations.
    • Protection of hands: Impervious gloves
    • Eye protection:
      Safety glasses
      Face protection
    • Body protection: Protective work clothing.
  • 9 Physical and chemical properties:

    • General Information

    • Form: Powder
    • Colour: White
    • Smell: Odourless
    •   Value/Range  Unit    Method      
    • Change in condition
    • Melting point/Melting range:                   609 ° C
    • Boiling point/Boiling range:       Not determined
    • Sublimation temperature / start:   Not determined

    • Flash point:                       Not applicable

    • Ignition temperature:              Not determined

    • Decomposition temperature:         Not determined

    • Danger of explosion:               Product is not explosive.

    • Critical values for explosion:
    • Lower:                             Not determined
    • Upper:                             Not determined

    • Steam pressure:                    Not determined

    • Density                at   20 ° C            4.52 g/cm³

    • Solubility in / Miscibility with
    • Water:                             Soluble
  • 10 Stability and reactivity

    • Thermal decomposition / conditions to be avoided:
      No decomposition if used and stored according to specifications.
    • Materials to be avoided:
      Water/moisture
      Bases
    • Dangerous reactions: No dangerous reactions known
    • Dangerous products of decomposition:
      Hydrogen chloride (HCl)
      Chlorine
      Metal oxide
  • 11 Toxicological information

    • Acute toxicity:
    • Primary irritant effect:
    • on the skin: Irritant for skin and mucous membranes.
    • on the eye: Irritant effect.
    • Sensitization: No sensitizing effect known.
    • Additional toxicological information:
      To the best of our knowledge the acute and chronic toxicity of this substance is not fully known.
      No classification data on carcinogenic properties of this material is available from the EPA, IARC, NTP, OSHA or ACGIH.
  • 12 Ecological information:

    • General notes:
      Do not allow material to be released to the environment without proper governmental permits.
      Water hazard class 1 (Self-assessment): slightly hazardous for water.
      Do not allow undiluted product or large quantities of it to reach ground water, water bodies or sewage system.
  • 13 Disposal considerations


    • Product:
    • Recommendation
      Consult state, local or national regulations for proper disposal.
      Hand over to disposers of hazardous waste.
      Must be specially treated under adherence to official regulations.

    • Uncleaned packagings:
    • Recommendation:
      Disposal must be made according to official regulations.
    • Recommended cleaning agent: Water, if necessary with cleaning agent.
  • 14 Transport information


    • Land transport ADR/RID and GGVS/GGVE (cross-border/domestic)
    • ADR/RID-GGVS/E Class:         None

    • Maritime transport IMDG/GGVSea:
    • IMDG/GGVSea Class:        None

    • Air transport ICAO-TI and IATA-DGR:
    • ICAO/IATA Class:          None

    • Transport/Additional information:
      Not dangerous according to the above specifications.
  • 15 Regulatory information


    • Designation according to EC guidelines:

    • Code letter and hazard designation of product: Xi Irritant

    • Risk phrases: 36/38 Irritating to eyes and skin.

    • Safety phrases:
      26    In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

    • National regulations

    • Information about limitation of use:
      For use only by technically qualified individuals.
      Employment restrictions concerning young persons must be observed.

    • Water hazard class:
      Water hazard class 1 (Self-assessment): slightly hazardous for water.
  • 16 Other information:

      Employers should use this information only as a supplement to other information gathered by them, and should make independent judgement of suitability of this information to ensure proper use and protect the health and safety of employees.  This information is furnished without warranty, and any use of the product not in conformance with this Material Safety Data Sheet, or in combination with any other product or process, is the responsibility of the user.

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