Holmium Oxide is a highly insoluble thermally stable Holmium source suitable for glass, optic and ceramic applications. Holmium oxide occurs in small quantities in the minerals monazite, gadolinite, and in other rare-earth minerals. Holmium metal easily oxidizes in air; therefore presence of holmium in nature is synonymous with that of holmium oxide. Holmium Oxide is generally immediately available in most volumes. Ultra high purity and high purity compositions improve both optical quality and usefulness as scientific standards. Nanoscale (See also Nanotechnology Information and Quantum Dots) elemental powders and suspensions, as alternative high surface area forms, may be considered. Holmium has the highest magnetic moment (10.6 µB) of any naturally occurring element and has been used to create the highest known magnetic fields as a pole piece or magnetic flux concentrator. Oxide compounds are not conductive to electricity. However, certain perovskite structured oxides are electronically conductive finding application in the cathode of solid oxide fuel cells and oxygen generation systems.
Rare Earth oxide compounds are basic anhydrides and can therefore react withacids and with strong reducing agents in redox reactions. They are compounds containing at least one oxygen anion and one metallic cation. They are typically insoluble in aqueous solutions (water) and extremely stable making them useful in ceramic structures as simple as producing clay bowls to advanced electronics and in light weight structural components in aerospace and electrochemical applications such as fuel cells in which they exhibit ionic conductivity. Holmium oxide is also available in pellets, pieces, sputtering targets, and tablets. Additional technical, research and safety (MSDS) information is available.
Holmium is a Block F, Group 3, Period 6 element. The number of electrons in each of Holmium's shells is 2, 8, 18, 29, 8, 2 and its electronic configuration is [Xe] 4f11 6s2. In its elemental form holmium's CAS number is 7440-60-0. The holmium atom has a radius of 174.3.pm and it's Van der Waals radius is unknown. Holmium is only slightly toxic. Holmium has the highest magnetic moment (10.6µB) of any naturally occurring element. Because of this it has been used to create the highest known magnetic fields by placing it within high strength magnets as a pole piece or magnetic flux concentrator. This magnetic property also has value in yttrium-iron-garnet(YIG) lasers for microwave equipment. Holmium is available as metal and compounds with purities from 99% to 99.999% (ACS grade to ultra-high purity); metals in the form of foil, sputtering target, and rod, and compounds as submicron and nanopowder. Holmium lases at a human eye safe 2.08 microns allowing its use in a variety of medical and dental applications in both yttrium-aluminum-garnet (YAG) and yttrium-lanthanum-fluoride (YLF) solid state lasers. The wavelength allows for use in silica fibers designed for shorter wavelengths while still providing the cutting strength of longer wave length equipment. Holmium was first discovered by J.L. Soret in 1878. See Holmium research below.
PACKAGING SPECIFICATIONS FOR BULK & RESEARCH QUANTITIES
Typical bulk packaging includes palletized plastic 5 gallon/25 kg. pails, fiber and steel drums to 1 ton super sacks in full container (FCL) or truck load (T/L) quantities. Research and sample quantities and hygroscopic, oxidizing or other air sensitive materials may be packaged under argon or vacuum. Shipping documentation includes a Certificate of Analysis and Material Safety Data Sheet (MSDS). Solutions are packaged in polypropylene, plastic or glass jars up to palletized 440 gallon liquid totes.
EX-VIVO COMPARISON OF AVAILABLE MORCELLATION DEVICES DURING HOLEP THROUGH OBJECTIVE PARAMETERS.
Cornu JN, Terrasa JB, Lukacs B.
J Endourol. 2012 Jan 19. [Epub ahead of print]
PMID:
22260635
[PubMed - as supplied by publisher]
[A meta-analysis of holmium laser enucleation of the prostate for benign prostatic hyperplasia].
Zhao CB, Li JC, Yuan PQ, Hong YQ, Lu B, Zhao SC.
Zhonghua Nan Ke Xue. 2011 Dec;17(12):1112-20. Chinese.
PMID:
22235682
[PubMed - in process]
[Causes, location and management of BPH surgery-related urethral stricture].
Long Z, He LY, Jiang XZ, Zhang YC, Wang GM, Pei XM, Huang K.
Zhonghua Nan Ke Xue. 2011 Dec;17(12):1097-100. Chinese.
PMID:
22235678
[PubMed - in process]
Laser Lithotripsy to Treat Basket Impaction during Mechanical Lithotripsy of a Pancreatic Duct Stone.
Hlaing C, Tarnasky P, Hambrick D.
JOP. 2011 Dec 23;13(1):101-3.
PMID:
22233959
[PubMed - in process]
Outpatient therapeutic nuclear oncology.
Turner JH.
Ann Nucl Med. 2012 Jan 7. [Epub ahead of print]
PMID:
22222779
[PubMed - as supplied by publisher]
Outcomes of transurethral removal of intravesical or intraurethral mesh following midurethral sling surgery.
Jo DJ, Lee YS, Oh TH, Ryu DS, Kwak KW.
Korean J Urol. 2011 Dec;52(12):829-34. Epub 2011 Dec 20.
PMID:
22216395
[PubMed - in process]
The efficacy and safety of ureteroscopy for ureteral calculi in pregnancy: our experience in 32 patients.
Bozkurt Y, Penbegul N, Soylemez H, Atar M, Sancaktutar AA, Yildirim K, Sak ME.
Urol Res. 2012 Jan 4. [Epub ahead of print]
PMID:
22215294
[PubMed - as supplied by publisher]
catena-Poly[[tetra-kis-(hexa-methyl-phospho-ramide-?O)bis-(nitrato-?O,O')holmium(III)] [silver(I)-di-?-sulfido-tungstate(VI)-di-?-sulfido]].
Zeng J, Tang G, Wei C.
Acta Crystallogr Sect E Struct Rep Online. 2011 Dec 1;67(Pt 12):m1724-5. Epub 2011 Nov 9.
PMID:
22199530
[PubMed - in process]
Selected Trace Elements in the Sacramento River, California: Occurrence and Distribution.
Taylor HE, Antweiler RC, Roth DA, Alpers CN, Dileanis P.
Arch Environ Contam Toxicol. 2011 Dec 23. [Epub ahead of print]
PMID:
22193863
[PubMed - as supplied by publisher]
Ureterorenoscopy with Holmium-Yttrium-Aluminum-Garnet Fragmentation Is a Safe and Efficient Technique for Stone Treatment in Patients with a Body Mass Index Superior to 30 kg/m(2).
Delorme G, Huu YN, Lillaz J, Bernardini S, Chabannes E, Guichard G, Bittard H, Kleinclauss F.
J Endourol. 2012 Jan 12. [Epub ahead of print]
PMID:
22192111
[PubMed - as supplied by publisher]
Ureteroscopic Lithotripsy for Distal Ureteral Calculi: Comparative Evaluation of Three Different Lithotriptors.
Salvadó JA, Mandujano R, Saez I, Saavedra A, Dell'oro A, Dominguez J, Trucco C.
J Endourol. 2012 Jan 4. [Epub ahead of print]
PMID:
22192101
[PubMed - as supplied by publisher]
[Relationship between morcellation efficiency and enucleated tissue weight in holmium laser enucleation of the prostate (HoLEP) for patients with benign prostatic hyperplasia].
Ishikawa R, Shitara T, Wakatabe Y, Kubo S, Hirayama T, Fujita T, Iwamura M, Baba S.
Nihon Hinyokika Gakkai Zasshi. 2011 Sep;102(5):675-8. Japanese.
PMID:
22191275
[PubMed - in process]
First collaborative experience with thulium laser ablation of localized upper urinary tract urothelial tumors using retrograde intra-renal surgery.
Defidio L, De Dominicis M, Di Gianfrancesco L, Fuchs G, Patel A.
Arch Ital Urol Androl. 2011 Sep;83(3):147-53.
PMID:
22184839
[PubMed - in process]
Treatment of ectopic intratracheal thyroid with a holmium laser.
Hall AB, Gifford TO, Sabatini PR.
Mil Med. 2011 Nov;176(11):1325-6.
PMID:
22165664
[PubMed - indexed for MEDLINE]
Characteristics of patients with fluid extravasation during retrograde ureteroscopic holmium laser lithotripsy for renal calculi.
Luo XM, Zhang C, Qian HJ, Song C, Yang SX.
Saudi Med J. 2011 Dec;32(12):1251-5.
PMID:
22159379
[PubMed - in process]
Potential of high-Z contrast agents in clinical contrast-enhanced computed tomography.
Nowak T, Hupfer M, Brauweiler R, Eisa F, Kalender WA.
Med Phys. 2011 Dec;38(12):6469.
PMID:
22149830
[PubMed - in process]
Successful outcome of flexible ureteroscopy with holmium laser lithotripsy for renal stones 2 cm or greater.
Takazawa R, Kitayama S, Tsujii T.
Int J Urol. 2011 Dec 6. doi: 10.1111/j.1442-2042.2011.02931.x. [Epub ahead of print]
PMID:
22145599
[PubMed - as supplied by publisher]
A case of large bladder hemangioma successfully treated with endoscopic yttrium aluminium garnet laser irradiation.
Takemoto J, Yamazaki Y, Sakai K.
Int J Urol. 2011 Dec;18(12):854-6. doi: 10.1111/j.1442-2042.2011.02879.x. Epub 2011 Oct 20.
PMID:
22142464
[PubMed - in process]
[Impacts of different transurethral prostatic resection procedures on male sexual function: meta-analysis of randomized controlled trials].
Zong HT, Peng XX, Yang CC, Zhang Y.
Zhonghua Nan Ke Xue. 2011 Nov;17(11):1014-8. Chinese.
PMID:
22141274
[PubMed - in process]
Single-operator cholangioscopy-guided laser lithotripsy in patients with difficult biliary and pancreatic ductal stones (with videos).
Maydeo A, Kwek BE, Bhandari S, Bapat M, Dhir V.
Gastrointest Endosc. 2011 Dec;74(6):1308-14.
PMID:
22136776
[PubMed - in process]
Material Safety Data Sheet
1 Identification of substance
Product details
Trade name Holmium (III) oxide
2 Composition/Data on components:
Chemical characterization: Designation: (CAS#)
Holmium (III) oxide (CAS# 12055-62-8), 100%
Identification number(s):
EINECS Number: 235-015-3
3 Hazards identification
Hazard designation: · void
Information pertaining to particular dangers for man and environment
Not applicable
4 First aid measures
After inhalation
Supply fresh air. If required, provide artificial respiration. Keep patient warm. Consult doctor if symptoms persist.
Seek immediate medical advice.
After skin contact
Instantly wash with water and soap and rinse thoroughly.
Seek immediate medical advice.
After eye contact
Rinse opened eye for several minutes under running water. Then consult doctor.
After swallowing Seek medical treatment.
5 Fire fighting measures
Suitable extinguishing agents
Use fire fighting measures that suit the environment.
Protective equipment:
Wear self-contained breathing apparatus.
Wear full protective suit.
Measures for environmental protection:
Do not allow material to be released to the environment without proper governmental permits.
Measures for cleaning/collecting: Collect mechanically.
Additional information:
See Section 7 for information on safe handling
See section 8 for information on personal protection equipment.
See Section 13 for information on disposal.
7 Handling and storage
Handling
Information for safe handling:
Keep containers tightly sealed.
Store in cool, dry place in tightly closed containers.
No special precautions necessary if used correctly.
Information about protection against explosions and fires:
The product is not flammable
Storage
Requirements to be met by storerooms and containers:
No special requirements.
Information about storage in one common storage facility:
Do not store together with acids.
Further information about storage conditions:
This product is hygroscopic.
Protect from carbon dioxide.
Avoid contact with air / oxygen.
Keep container tightly sealed.
Store in cool, dry conditions in well sealed containers.
8 Exposure controls and personal protection
Additional information about design of technical systems:
Properly operating chemical fume hood designed for hazardous chemicals and having an average face velocity of at least 100 feet per minute.
Components with critical values that require monitoring at the workplace:
Not required.
Additional information: No data
Personal protective equipment
General protective and hygienic measures
The usual precautionary measures should be adhered to in handling the chemicals.
Keep away from foodstuffs, beverages and food.
Instantly remove any soiled and impregnated garments.
Wash hands during breaks and at the end of the work.
Breathing equipment: Use breathing protection with high concentrations.
Protection of hands: Impervious gloves
Eye protection: Safety glasses
Body protection: Protective work clothing.
9 Physical and chemical properties:
General Information
Form: Lump
Colour: Beige
Smell: Odourless
Value/Range Unit Method
Change in condition
Melting point/Melting range: 2360 ° C
Boiling point/Boiling range: 3900 ° C
Sublimation temperature / start: Not determined
Flash point: Not applicable
Inflammability (solid, gaseous) Product is not inflammable.
Ignition temperature: Not determined
Decomposition temperature: Not determined
Danger of explosion: Product is not explosive.
Critical values for explosion:
Lower: Not determined
Upper: Not determined
Steam pressure: Not determined
Density at 20 ° C 8.36 g/cm³
Solubility in / Miscibility with
Water: Insoluble
10 Stability and reactivity
Thermal decomposition / conditions to be avoided:
No decomposition if used and stored according to specifications.
Materials to be avoided:
Acids
Air
Carbon dioxide
Dangerous reactions: No dangerous reactions known
Dangerous products of decomposition: Metal oxide
11 Toxicological information
Acute toxicity:
Primary irritant effect:
on the skin: Powder: irritant effect
on the eye: Powder: irritant effect
Sensitization: No sensitizing effect known.
Additional toxicological information:
To the best of our knowledge the acute and chronic toxicity of this substance is not fully known.
No classification data on carcinogenic properties of this material is available from the EPA, IARC, NTP, OSHA or ACGIH.
12 Ecological information:
General notes:
Do not allow material to be released to the environment without proper governmental permits.
Generally not hazardous for water.
13 Disposal considerations
Product:
Recommendation
Consult state, local or national regulations for proper disposal.
Hand over to disposers of hazardous waste.
Must be specially treated under adherence to official regulations.
Uncleaned packagings:
Recommendation:
Disposal must be made according to official regulations.
14 Transport information
Land transport ADR/RID and GGVS/GGVE (cross-border/domestic)
ADR/RID-GGVS/E Class: None
Maritime transport IMDG/GGVSea:
IMDG/GGVSea Class: None
Air transport ICAO-TI and IATA-DGR:
ICAO/IATA Class: None
Transport/Additional information:
Not dangerous according to the above specifications.
15 Regulatory information
Designation according to EC guidelines:
Observe the normal safety regulations when handling chemicals
The product is not subject to identification regulations under EC Directives and the Ordinance on Hazardous Materials (GefStoffV).
National regulations
Information about limitation of use:
For use only by technically qualified individuals.
Water hazard class: Generally not hazardous for water.
16 Other information:
Employers should use this information only as a supplement to other information gathered by them, and should make independent judgement of suitability of this information to ensure proper use and protect the health and safety of employees. This information is furnished without warranty, and any use of the product not in conformance with this Material Safety Data Sheet, or in combination with any other product or process, is the responsibility of the user.
Holmium Oxide is a highly insoluble thermally stable Holmium source suitable for glass, optic and ceramic applications. Holmium oxide occurs in small quantities in the minerals monazite, gadolinite, and in other rare-earth minerals. Holmium metal easily oxidizes in air; therefore presence of holmium in nature is synonymous with that of holmium oxide. Holmium Oxide is generally immediately available in most volumes. Ultra high purity and high purity compositions improve both optical quality and usefulness as scientific standards. Nanoscale (See also Nanotechnology Information and Quantum Dots) elemental powders and suspensions, as alternative high surface area forms, may be considered. Holmium has the highest magnetic moment (10.6 µB) of 
any naturally occurring element and has been used to create the highest known magnetic fields as a pole piece or magnetic flux concentrator. Oxide compounds are not conductive to electricity. However, certain perovskite structured oxides are electronically conductive finding application in the cathode of solid oxide fuel cells and oxygen generation systems.
Rare Earth oxide compounds are basic anhydrides and can therefore react withacids and with strong reducing agents in redox reactions. They are compounds containing at least one oxygen anion and one metallic cation. They are typically insoluble in aqueous solutions (water) and extremely stable making them useful in ceramic structures as simple as producing clay bowls to advanced electronics and in light weight structural components in aerospace and electrochemical applications such as fuel cells in which they exhibit ionic conductivity. Holmium oxide is also available in pellets, pieces, sputtering targets, and tablets. Additional technical, research and safety (MSDS) information is available.
Holmium is a Block F, Group 3, Period 6 element. The number of electrons in each of Holmium's shells is 2, 8, 18, 29, 8, 2 and its electronic configuration is [Xe] 4f11 6s2. In its elemental form holmium's CAS number is 7440-60-0. The holmium atom has a radius of 174.3.pm and it's Van der Waals radius is unknown. Holmium is only slightly toxic. Holmium has the highest magnetic moment (10.6µB) of any naturally occurring 
element. Because of this it has been used to create the highest known magnetic fields by placing it within high strength magnets as a pole piece or magnetic flux concentrator. This magnetic property also has value in yttrium-iron-garnet
(YIG) lasers for microwave equipment. Holmium is available as metal and compounds with purities from 99% to 99.999% (ACS grade to ultra-high purity); metals in the form of foil, sputtering target, and rod, and compounds as submicron and nanopowder. Holmium lases at a human eye safe 2.08 microns allowing its use in a variety of medical and dental applications in both yttrium-aluminum-garnet (YAG) and yttrium-lanthanum-fluoride (YLF) solid state lasers. The wavelength allows for use in silica fibers designed for shorter wavelengths while still providing the cutting strength of longer wave length equipment. Holmium was first discovered by J.L. Soret in 1878. See Holmium research below. 
