About Oxalates

Structure of an Oxalate Anion

Oxalate is an anion with the formula C2O2-4, also written [(COO)2]2-. The ion forms salts or coordination complexes with many metals. The oxalate salts of alkali earth metals, such as calcium oxalate, a major component of human kidney stones that is also found in some plants as sharp crystals known as raphides, are insoluble in water and irritating to the skin and digestive tract. Calcium oxalate is used in the production of ceramics, while strontium oxalate and barium oxalate are used as reducing agents in laboratory chemistry and pyrotechnics.

Other oxalates used as chemical reagents include potassium hydrogenoxalate, also known as salt of sorrel, due to its occurrence in the sorrel plant. It is used in photography and for the removal of ink stains. Ferric oxalate is a chemical compound used in platinum printmaking, while cobalt oxalate is used in the production of cobalt catalysts. Oxalates may also be used in some instances as sources of the metals they contain.

Recent Research & Development for Oxalates

Does green tea consumption increase urinary oxalate excretion? Results of a prospective trial in healthy men., Chen, Kang, Chen Dong, Lan Chuangxin, Liang Xiongfa, Zeng Tao, Huang Jian, Duan Xiaolu, Kong Zhenzhen, Li Shujue, Tiselius Hans-Göran, et al. , Int Urol Nephrol, 2018 Jan, Volume 50, Issue 1, p.29-33, (2018)

Regulation of bone mineral density in the grey squirrel, Sciurus carolinensis: Bioavailability of calcium oxalate, and implications for bark stripping., Nichols, C P., Gregory N G., Goode N, Gill R M. A., and Drewe J A. , J Anim Physiol Anim Nutr (Berl), 2018 Feb, Volume 102, Issue 1, p.330-336, (2018)

Protective Effects of Pistacia lentiscus L. fruit extract against calcium oxalate monohydrate induced proximal tubular injury., Cheraft-Bahloul, Nassima, Husson Cécile, Ourtioualous Meriam, Sinaeve Sébastien, Atmani Djebbar, Stévigny Caroline, Nortier Joëlle L., and Antoine Marie-Hélène , J Ethnopharmacol, 2017 Sep 14, Volume 209, p.248-254, (2017)

Can Randall's plug composed of calcium oxalate form via the free particle mechanism?, Grases, F, and Söhnel O , BMC Urol, 2017 Sep 08, Volume 17, Issue 1, p.80, (2017)

Time-dependent subcellular structure injuries induced by nano-/micron-sized calcium oxalate monohydrate and dihydrate crystals., Sun, Xin-Yuan, Yu Kai, and Ouyang Jian-Ming , Mater Sci Eng C Mater Biol Appl, 2017 Oct 01, Volume 79, p.445-456, (2017)

Invited response to Recurrence of oxalate nephropathy after isolated kidney transplantation for primary hyperoxaluria type 2., Dhondup, Tsering, Lorenz Elizabeth C., Milliner Dawn S., and Lieske John C. , Am J Transplant, 2017 Nov 21, (2017)

Inhibitory effect of an aqueous extract of Radix Paeoniae Alba on calcium oxalate nephrolithiasis in a rat model., Li, Xiaoran, Wang Wenyun, Su Yu, Yue Zhongjin, and Bao Junsheng , Ren Fail, 2017 Nov, Volume 39, Issue 1, p.120-129, (2017)

Calcium oxalate crystals induces tight junction disruption in distal renal tubular epithelial cells by activating ROS/Akt/p38 MAPK signaling pathway., Yu, Lei, Gan Xiuguo, Liu Xukun, and An Ruihua , Ren Fail, 2017 Nov, Volume 39, Issue 1, p.440-451, (2017)

Discrimination Between Calcium Hydroxyapatite and Calcium Oxalate Using Multienergy Spectral Photon-Counting CT., Kirkbride, Tracy E., Raja Aamir Y., Müller Kristin, Bateman Christopher J., Becce Fabio, and Anderson Nigel G. , AJR Am J Roentgenol, 2017 Nov, Volume 209, Issue 5, p.1088-1092, (2017)

Urinary oxalate to creatinine ratios in healthy Turkish schoolchildren., Dursun, Ismail, Çelik İlknur, Poyrazoglu Hakan M., Köse Kader, Tanrıkulu Esen, Sahin Habibe, Yılmaz Kenan, Öztürk Ahmet, Yel Sibel, Gündüz Zübeyde, et al. , Ren Fail, 2017 Nov, Volume 39, Issue 1, p.146-152, (2017)

Total flavonoids of Desmodium styracifolium attenuates the formation of hydroxy-L-proline-induced calcium oxalate urolithiasis in rats., Zhou, Jianfu, Jin Jing, Li Xiong, Zhao Zhongxiang, Zhang Lei, Wang Qian, Li Jing, Zhang Qiuhong, and Xiang Songtao , Urolithiasis, 2017 May 31, (2017)

Properties of intermediates in the catalytic cycle of oxalate oxidoreductase and its suicide inactivation by pyruvate., Pierce, Elizabeth, Mansoorabadi Steven O., Can Mehmet, Reed George H., and Ragsdale Stephen W. , Biochemistry, 2017 May 17, (2017)

Determination of Escitalopram Oxalate and L-Methylfolate in Tablet by Spectrophotometric and Reverse Phase High-Performance Liquid Chromatographic Methods., Sheladia, Seema, and Patel Bhavesh , J Chromatogr Sci, 2017 May 01, Volume 55, Issue 5, p.550-555, (2017)

The oxalyl-CoA synthetase-regulated oxalate and its distinct effects on resistance to bacterial blight and aluminium toxicity in rice., Peng, C, Liang X, Liu E-E, Zhang J-J, and Peng X-X , Plant Biol (Stuttg), 2017 May, Volume 19, Issue 3, p.345-353, (2017)

Chemical modification of oxalate decarboxylase to improve adsorption capacity., Lin, Rihui, He Junbin, Wu Jia, Cai Xinghua, Long Han, Chen Shengfeng, and Liu Haiqian , Int J Biol Macromol, 2017 May, Volume 98, p.495-501, (2017)