About Oxalates

Structure of an Oxalate Anion

Oxalate is an anion with the formula C2O2-4, also written [(COO)2]2-. The ion forms salts or coordination complexes with many metals. The oxalate salts of alkali earth metals, such as calcium oxalate, a major component of human kidney stones that is also found in some plants as sharp crystals known as raphides, are insoluble in water and irritating to the skin and digestive tract. Calcium oxalate is used in the production of ceramics, while strontium oxalate and barium oxalate are used as reducing agents in laboratory chemistry and pyrotechnics.

Other oxalates used as chemical reagents include potassium hydrogenoxalate, also known as salt of sorrel, due to its occurrence in the sorrel plant. It is used in photography and for the removal of ink stains. Ferric oxalate is a chemical compound used in platinum printmaking, while cobalt oxalate is used in the production of cobalt catalysts. Oxalates may also be used in some instances as sources of the metals they contain.

Recent Research & Development for Oxalates

Exosomes from miR-20b-3p-overexpressing stromal cells ameliorate calcium oxalate deposition in rat kidney., Shi, Jing, Duan Junyao, Gong Huijie, Pang Yuewen, Wang Ling, and Yan Yongji , J Cell Mol Med, 2019 Sep 05, (2019)

Oxalate-degrading bacteria, including Oxalobacter formigenes, colonise the gastrointestinal tract of healthy koalas (Phascolarctos cinereus) and those with oxalate nephrosis., Speight, K N., Houston-Francis M, Mohammadi-Dehcheshmeh M, Ebrahimie E, Saputra S, and Trott D J. , Aust Vet J, 2019 May, Volume 97, Issue 5, p.166-170, (2019)

Mechanisms of plant protection against two oxalate-producing fungal pathogens by oxalotrophic strains of Stenotrophomonas spp., Marina, María, Romero Fernando M., Villarreal Natalia M., Medina Andrés J., Gárriz Andrés, Rossi Franco R., Martinez Gustavo A., and Pieckenstain Fernando L. , Plant Mol Biol, 2019 Jun 12, (2019)

Porous CoC₂O₄/Graphene Oxide Nanocomposite for Advanced Potassium-Ion Storage., Wang, Lifeng, Wei Kaiyuan, Zhang Pengjun, Wang Hong, Qi Xiujun, Wu Xuan, Zhao Wei, and Ju Zhicheng , J Nanosci Nanotechnol, 2019 Jun 01, Volume 19, Issue 6, p.3610-3615, (2019)

Mitochondria Permeability Transition versus Necroptosis in Oxalate-Induced AKI., Mulay, Shrikant Ramesh, Honarpisheh Mohsen M., Foresto-Neto Orestes, Shi Chongxu, Desai Jyaysi, Zhao Zhi Bo, Marschner Julian A., Popper Bastian, Buhl Ewa Miriam, Boor Peter, et al. , J Am Soc Nephrol, 2019 Jul 11, (2019)

Efficacy and safety of bupropion hydrochloride extended-release versus escitalopram oxalate in Chinese patients with major depressive disorder: Results from a randomized, double-blind, non-inferiority trial., Shen, Yifeng, Zhao Qian, Yu Yimin, Tan Yunlong, Zhang Honggeng, Xu Xiufeng, Wang Zhiyang, Li Yan, Hu Jingqiu, Zhong Jinhua, et al. , J Affect Disord, 2019 Jul 05, Volume 257, p.143-149, (2019)

Modulatory effects of fibronectin on calcium oxalate crystallization, growth, aggregation, adhesion on renal tubular cells, and invasion through extracellular matrix., Khamchun, Supaporn, Sueksakit Kanyarat, Chaiyarit Sakdithep, and Thongboonkerd Visith , J Biol Inorg Chem, 2019 Jan 30, (2019)

Daily Green Tea Infusions in Hypercalciuric Renal Stone Patients: No Evidence for Increased Stone Risk Factors or Oxalate-Dependent Stones., Rode, Julie, Bazin Dominique, Dessombz Arnaud, Benzerara Yahia, Letavernier Emmanuel, Tabibzadeh Nahid, Hoznek Andras, Tligui Mohamed, Traxer Olivier, Daudon Michel, et al. , Nutrients, 2019 Jan 24, Volume 11, Issue 2, (2019)

Crystal Growth in the Thorium-TEDGA-Oxalate-Nitrate System: Description and Comparison of the Main Structural Features., Farger, Pierre, Haidon Blaise, Roussel Pascal, Arab-Chapelet Bénédicte, and Rivenet Murielle , Inorg Chem, 2019 Jan 08, (2019)

A GH family 28 endo-polygalacturonase from the brown-rot fungus Fomitopsis palustris: Purification, gene cloning, enzymatic characterization and effects of oxalate., Tanaka, Yuki, Suzuki Tomohiro, Nakamura Luna, Nakamura Mai, Ebihara Shun, Kurokura Takeshi, Iigo Masayuki, Dohra Hideo, Habu Naoto, and Konno Naotake , Int J Biol Macromol, 2019 Feb 15, Volume 123, p.108-116, (2019)

Systemic Succinate Homeostasis and Local Succinate Signaling Affect Blood Pressure and Modify Risks for Calcium Oxalate Lithogenesis., Khamaysi, Ahlam, Anbtawee-Jomaa Shireen, Fremder Moran, Eini-Rider Hadar, Shimshilashvili Liana, Aharon Sara, Aizenshtein Elina, Shlomi Tomer, Noguchi Audrey, Springer Danielle, et al. , J Am Soc Nephrol, 2019 Feb 06, (2019)

Photogeneration of hydroxyl radical in Fe(III)-citrate-oxalate system for the degradation of fluconazole: mechanism and products., Wan, Dong, Zhang Guofei, Chen Yong, Lu Xiye, and Zuo Yuegang , Environ Sci Pollut Res Int, 2019 Feb 01, (2019)

Identification of urine biomarkers for calcium-oxalate urolithiasis in adults based on UPLC-Q-TOF/MS., Wang, Xiangyu, Wang Miaomiao, Ruan Jimeng, Zhao Shurui, Xiao Jing, and Tian Ye , J Chromatogr B Analyt Technol Biomed Life Sci, 2019 Aug 15, Volume 1124, p.290-297, (2019)

A Long-term Evaluation of Experimental Potassium Oxalate Concentrations on Dentin Hypersensitivity Reduction: A Triple-Blind Randomized Clinical Trial., Galvão, Alexia da Mata, Zeola Lívia Fávaro, Moura Guilherme Faria, Teixeira Daniela Navarro Ri, Gonzaga Ramon Corrêa de, da Silva Gisele Rodrigues, and Soares Paulo Vinícius , J Dent, 2019 Aug 12, p.103180, (2019)