A Smart Europium-Ruthenium Complex as Anticancer Prodrug: Controllable Drug Release and Real-Time Monitoring under Different Light Excitations.

Title A Smart Europium-Ruthenium Complex as Anticancer Prodrug: Controllable Drug Release and Real-Time Monitoring under Different Light Excitations.
Authors H. Li; C. Xie; R. Lan; S. Zha; C.F. Chan; W.Y. Wong; K.L. Ho; B.Dow Chan; Y. Luo; J.X. Zhang; G.L. Law; W.C.S. Tai; J.C.G. Bünzli; K.L. Wong
Journal J Med Chem
DOI 10.1021/acs.jmedchem.7b01162
Abstract

A unique, dual-function, photoactivatable anticancer prodrug, RuEuL, has been tailored that features a ruthenium(II) complex linked to a cyclen-europium chelate via a ?-conjugated bridge. Under irradiation at 488 nm, the dark-inactive prodrug undergoes photodissociation, releasing the DNA-damaging ruthenium species. Under evaluation-window irradiation (?irr = one-photon 350 nm or two-photon 700 nm), the drug delivery process can be quantitatively monitored in real-time because of the long-lived red europium emission. Linear relationships between released drug concentration and ESI-MS or luminescence responses are established. Finally, the efficiency of the new prodrug is demonstrated both in vitro RuEuL anticancer prodrug over some existing ones and open the way for decisive improvements in multipurpose prodrugs.

Citation H. Li; C. Xie; R. Lan; S. Zha; C.F. Chan; W.Y. Wong; K.L. Ho; B.Dow Chan; Y. Luo; J.X. Zhang; G.L. Law; W.C.S. Tai; J.C.G. Bünzli; K.L. Wong.A Smart Europium-Ruthenium Complex as Anticancer Prodrug: Controllable Drug Release and Real-Time Monitoring under Different Light Excitations.. J Med Chem. 2017;60(21):89238932. doi:10.1021/acs.jmedchem.7b01162

Related Elements

Europium

See more Europium products. Europium (atomic symbol: Eu, atomic number: 63) is a Block F, Group 3, Period 6 element with an atomic radius of 151.964. Europium Bohr ModelThe number of electrons in each of Europium's shells is 2, 8, 18, 25, 8, 2 and its electron configuration is [Xe]4f7 6s2. The europium atom has an atomic radius of 180 pm and a Van der Waals radius of 233 pm. Europium was discovered by Eugène-Anatole Demarçay in 1896, however, he did not isolate it until 1901. Europium was named after the continent of Europe.Elemental Europium Picture Europium is a member of the lanthanide or rare earth series of metals. In its elemental form, it has a silvery-white appearance but it is rarely found without oxide discoloration. Europium is found in many minerals including bastnasite, monazite, xenotime and loparite. It is not found in nature as a free element.

Ruthenium

See more Ruthenium products. Ruthenium (atomic symbol: Ru, atomic number: 44) is a Block D, Group 8, Period 5 element with an atomic weight of 101.07. Ruthenium Bohr ModelThe number of electrons in each of ruthenium's shells is [2, 8, 18, 15, 1] and its electron configuration is [Kr] 4d7 5s1. The ruthenium atom has a radius of 134 pm and a Van der Waals radius of 207 pm. Ruthenium was discovered by Jędrzej Śniadecki in 1807. It was first recognized as a distinct element by Karl Ernst Claus in 1844. Elemental RutheniumIn its elemental form, ruthenium has a silvery white metallic appearance. Ruthenium is a rare transition metal belonging to the platinum group of metals. It is found in pentlandite, pyroxenite, and platinum group metal ores. The name Ruthenium originates from the Latin word "Ruthenia," meaning Russia.

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