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Arsenic Oxide Nanoparticles / Nanopowder

CAS #:

Linear Formula:

As2O3

MDL Number:

MFCD00003433

EC No.:

215-481-4

ORDER

PRODUCT Product Code ORDER SAFETY DATA TECHNICAL DATA
(2N) 99% Arsenic Oxide Nanopowder
AS-OX-02-NP
Pricing > SDS > Data Sheet >
(3N) 99.9% Arsenic Oxide Nanopowder
AS-OX-03-NP
Pricing > SDS > Data Sheet >
(4N) 99.99% Arsenic Oxide Nanopowder
AS-OX-04-NP
Pricing > SDS > Data Sheet >
(5N) 99.999% Arsenic Oxide Nanopowder
AS-OX-05-NP
Pricing > SDS > Data Sheet >

Arsenic Oxide Nanoparticles / Nanopowder Properties

Compound Formula

As2O3

Molecular Weight

197.84

Appearance

White Powder

Melting Point

312.2° C(594° F)

Boiling Point

465° C(869° F)

Density

3.74 g/cm3

Exact Mass

197.828 g/mol

Monoisotopic Mass

395.655876 Da

Arsenic Oxide Nanoparticles / Nanopowder Health & Safety Information

Signal Word Danger
Hazard Statements H300-H314-H350-H410
Hazard Codes T+,N
Precautionary Statements P301+P330+P331-P405-P501
Risk Codes 45-28-34-50/53
Safety Statements 53-45-60-61
RTECS Number CG3325000
Transport Information UN 1561 6.1/PG 2
WGK Germany 3
GHS Pictograms

View and Print SDS

SAFETY DATA SHEET

Date Accessed: 06/23/2017
Date Revised: 05/15/2015

SECTION 1. IDENTIFICATION

Product Name: Arsenic Oxide Nanoparticles / Nanopowder

Product Number: All applicable American Elements product codes, e.g. AS-OX-02-NP , AS-OX-03-NP , AS-OX-04-NP , AS-OX-05-NP

CAS #: 1327-53-3

Relevant identified uses of the substance: Scientific research and development

Supplier details:
American Elements
1093 Broxton Ave. Suite 2000
Los Angeles, CA 90024
Tel: +1 310-208-0551
Fax: +1 310-208-0351

Emergency telephone number:
Domestic, North America +1 800-424-9300
International +1 703-527-3887


SECTION 2. HAZARDS IDENTIFICATION

Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
GHS06 Skull and crossbones
Acute Tox. 2 H300 Fatal if swallowed.
GHS08 Health hazard
Carc. 1A H350 May cause cancer.
GHS05 Corrosion
Skin Corr. 1B H314 Causes severe skin burns and eye damage.
Eye Dam. 1 H318 Causes serious eye damage.
Hazards not otherwise classified
No information known.
Label elements
Labelling according to Regulation (EC) No 1272/2008
The substance is classified and labeled according to the CLP regulation.
Hazard pictograms

Corrosion - GHS05 Skull and Crossbones - GHS06 Health Hazard - GHS08

GHS05
GHS06
GHS08
Signal word
Danger
Hazard statements
H300 Fatal if swallowed.
H314 Causes severe skin burns and eye damage.
H350 May cause cancer.
Precautionary statements
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P301+P330+P331 IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
P405 Store locked up.
P501 Dispose of contents/container in accordance with local/regional/
national/international regulations.
WHMIS classification
D1A - Very toxic material causing immediate and serious toxic effects
D2A - Very toxic material causing other toxic effects
E - Corrosive material
Classification system
HMIS ratings (scale 0-4)
(Hazardous Materials Identification System)
HEALTH
FIRE
REACTIVITY
3


Health (acute effects) = 3
Flammability = 0
Physical Hazard = 0
Other hazards
Results of PBT and vPvB assessment
PBT:
Not applicable.
vPvB:
Not applicable.


SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS

Chemical characterization: Substances
CAS# Description:
1327-53-3 Arsenic(III) oxide
Identification number(s):
EC number:
215-481-4
Index number:
033-003-00-0


SECTION 4. FIRST AID MEASURES

Description of first aid measures
General information
Immediately remove any clothing soiled by the product.
In case of irregular breathing or respiratory arrest provide artificial respiration.
After inhalation
Supply fresh air. If required, provide artificial respiration. Keep patient warm.
Seek immediate medical advice.
After skin contact
Immediately wash with water and soap and rinse thoroughly.
Seek immediate medical advice.
After eye contact
Rinse opened eye for several minutes under running water. Then consult a doctor.
After swallowing
Do not induce vomiting; immediately call for medical help.
Information for doctor
Most important symptoms and effects, both acute and delayed
Causes severe skin burns.
Causes serious eye damage.
Indication of any immediate medical attention and special treatment needed
No further relevant information available.


SECTION 5. FIREFIGHTING MEASURES

Extinguishing media
Suitable extinguishing agents
Carbon dioxide, extinguishing powder or water spray. Fight larger fires wi
th water spray or alcohol resistant foam.
Special hazards arising from the substance or mixture
If this product is involved in a fire, the following can be released:
Toxic metal oxide fume
Advice for firefighters
Protective equipment:
Wear self-contained respirator.
Wear fully protective impervious suit.


SECTION 6. ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment and emergency procedures
Wear protective equipment. Keep unprotected persons away.
Ensure adequate ventilation
Environmental precautions:
Do not allow material to be released to the environment without proper governmental permits.
Methods and material for containment and cleaning up:
Use neutralizing agent.
Dispose of contaminated material as waste according to section 13.
Ensure adequate ventilation.
Prevention of secondary hazards:
No special measures required.
Reference to other sections
See Section 7 for information on safe handling
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.


SECTION 7. HANDLING AND STORAGE

Handling
Precautions for safe handling
Keep container tightly sealed.
Store in cool, dry place in tightly closed containers.
Ensure good ventilation at the workplace.
Open and handle container with care.
Information about protection against explosions and fires:
No information known.
Conditions for safe storage, including any incompatibilities
Storage
Requirements to be met by storerooms and receptacles:
No special requirements.
Information about storage in one common storage facility:
Store away from metal hydrides
Do not store together with acids.
Store away from strong bases.
Store away from oxidizing agents.
Store away from reducing agents.
Further information about storage conditions:
Keep container tightly sealed.
Store in cool, dry conditions in well sealed containers.
Specific end use(s)
No further relevant information available.


SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION

Additional information about design of technical systems:
Properly operating chemical fume hood designed for hazardous chemicals and having an average face velocity of at least 100 feet per minute.
Control parameters
Components with limit values that require monitoring at the workplace:
1327-53-3 Arsenic(III) oxide (100.0%)
PEL (USA) Long-term value: 0.01 mg/m³
as As; 29CFR1910.1018
REL (USA) Long-term value: 0.5 mg/m³
as Sb
TLV (USA) Long-term value: 0.01 mg/m³
EV (Canada) Short-term value: 0.05 mg/m³
Long-term value: 0.01 mg/m³
as As
Additional information:
No data
Exposure controls
Personal protective equipment
General protective and hygienic measures
The usual precautionary measures for handling chemicals should be followed.
Keep away from foodstuffs, beverages and feed.
Remove all soiled and contaminated clothing immediately.
Wash hands before breaks and at the end of work.
Store protective clothing separately.
Avoid contact with the eyes and skin.
Maintain an ergonomically appropriate working environment.
Breathing equipment:
Use suitable respirator when high concentrations are present.
Recommended filter device for short term use:
Use a respirator with type P100 (USA) or P3 (EN 143) cartridges as a backup to engineering controls. Risk assessment should be performed to determine if air-purifying respirators are appropriate. Only use equipment tested and approved under appropriate government standards.
Protection of hands:
Impervious gloves
Check protective gloves prior to each use for their proper condition.
The selection of suitable gloves not only depends on the material, but also on quality. Quality will vary from manufacturer to manufacturer.
Material of gloves
Nitrile rubber, NBR
Penetration time of glove material (in minutes)
480
Glove thickness
0.11 mm
Eye protection:
Tightly sealed goggles
Full face protection
Body protection:
Protective work clothing.


SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES

Information on basic physical and chemical properties
General Information
Appearance:
Form: Powder or solid in various forms
Color: White
Odor: Odorless
Odor threshold: Not determined.
pH-value: Not applicable.
Change in condition
Melting point/Melting range: 312.3 °C (594 °F)
Boiling point/Boiling range: 465 °C (869 °F) (subl)
Sublimation temperature / start: Not determined
Flammability (solid, gaseous)
Not determined.
Ignition temperature: Not determined
Decomposition temperature: Not determined
Auto igniting: Not determined.
Danger of explosion: Not determined.
Explosion limits:
Lower: Not determined
Upper: Not determined
Vapor pressure: Not applicable.
Density at 20 °C (68 °F): 3.74 g/cm³ (31.21 lbs/gal)
Relative density
Not determined.
Vapor density
Not applicable.
Evaporation rate
Not applicable.
Solubility in / Miscibility with Water at 20 °C (68 °F): 37 g/l
Partition coefficient (n-octanol/water): Not determined.
Viscosity:
dynamic: Not applicable.
kinematic: Not applicable.
Other information
No further relevant information available.


SECTION 10. STABILITY AND REACTIVITY

Reactivity
No information known.
Chemical stability
Stable under recommended storage conditions.
Thermal decomposition / conditions to be avoided:
Decomposition will not occur if used and stored according to specifications.
Possibility of hazardous reactions
Reacts with strong oxidizing agents
Conditions to avoid
No further relevant information available.
Incompatible materials:
Acids
Bases
Oxidizing agents
Reducing agents
Metal hydrides
Hazardous decomposition products:
Toxic metal oxide fume


SECTION 11. TOXICOLOGICAL INFORMATION

Information on toxicological effects
Acute toxicity:
Fatal if swallowed.
Swallowing will lead to a strong corrosive effect on mouth and throat and to the danger of perforation of esophagus and stomach.
The Registry of Toxic Effects of Chemical Substances (RTECS) contains acute toxicity data for this substance.
LD/LC50 values that are relevant for classification:
No data
Skin irritation or corrosion:
Causes severe skin burns.
Eye irritation or corrosion:
Causes serious eye damage
Sensitization:
No sensitizing effects known.
Germ cell mutagenicity:
The Registry of Toxic Effects of Chemical Substances (RTECS) contains mutation data for this substance.
Carcinogenicity:
May cause cancer.
EPA-A: human carcinogen: sufficient evidence from epidemiologic studies to support a causal association between exposure and cancer.
IARC-1: Carcinogenic to humans: sufficient evidence of carcinogenicity.
ACGIH A1: Confirmed human carcinogen: Agent is carcinogenic to humans based on epidemiologic studies of, or convincing clinical evidence in, exposed humans.
Carcinogen as defined by OSHA.
NTP-K: Known to be carcinogenic: sufficient evidence from human studies.
The Registry of Toxic Effects of Chemical Substances (RTECS) contains tumorigenic and/or carcinogenic and/or neoplastic data for this substance.
Reproductive toxicity:
The Registry of Toxic Effects of Chemical Substances (RTECS) contains reproductive data for this substance.
Specific target organ system toxicity - repeated exposure:
No effects known.
Specific target organ system toxicity - single exposure:
No effects known.
Aspiration hazard:
No effects known.
Subacute to chronic toxicity:
No effects known.
Additional toxicological information:
To the best of our knowledge the acute and chronic toxicity of this substance is not fully known.
Carcinogenic categories
OSHA-Ca (Occupational Safety & Health Administration)
Substance is not listed.


SECTION 12. ECOLOGICAL INFORMATION

Toxicity
Aquatic toxicity:
No further relevant information available.
Persistence and degradability
No further relevant information available.
Bioaccumulative potential
No further relevant information available.
Mobility in soil
No further relevant information available.
Ecotoxical effects:
Remark:
Very toxic for aquatic organisms
Additional ecological information:
General notes:
Do not allow material to be released to the environment without proper governmental permits.
Do not allow product to reach ground water, water course or sewage system, even in small quantities.
Danger to drinking water if even extremely small quantities leak into the ground.
Also poisonous for fish and plankton in water bodies.
May cause long lasting harmful effects to aquatic life.
Avoid transfer into the environment.
Very toxic for aquatic organisms
Results of PBT and vPvB assessment
PBT:
Not applicable.
vPvB:
Not applicable.
Other adverse effects
No further relevant information available.


SECTION 13. DISPOSAL CONSIDERATIONS

Waste treatment methods
Recommendation
Consult state, local or national regulations to ensure proper disposal.
Uncleaned packagings:
Recommendation:
Disposal must be made according to official regulations.


SECTION 14. TRANSPORT INFORMATION

UN-Number
DOT, IMDG, IATA
UN1561
UN proper shipping name
DOT
RQ Arsenic trioxide
IMDG, IATA
ARSENIC TRIOXIDE
Transport hazard class(es)
DOT
Class
6.1 Toxic substances.
Label
6.1
Class
6.1 (T5) Toxic substances
Label
6.1
IMDG, IATA
Class
6.1 Toxic substances.
Label
6.1
Packing group
DOT, IMDG, IATA
II
Environmental hazards:
Environmentally hazardous substance, solid
Special precautions for user
Warning: Toxic substances
EMS Number:
F-A,S-A
Transport in bulk according to Annex II of MARPOL73/78 and the IBC Code
Not applicable.
Transport/Additional information:
DOT
Hazardous substance:
1 lbs, 0.454 kg
Marine Pollutant (DOT):
No
UN "Model Regulation":
UN1561, Arsenic trioxide, 6.1, Il


SECTION 15. REGULATORY INFORMATION

Safety, health and environmental regulations/legislation specific for the substance or mixture
National regulations
All components of this product are listed in the U.S. Environmental Protection Agency Toxic Substances Control Act Chemical substance Inventory.
All components of this product are listed on the Canadian Domestic Substances List (DSL).
SARA Section 313 (specific toxic chemical listings)
1327-53-3 Arsenic(III) oxide
California Proposition 65
Prop 65 - Chemicals known to cause cancer
1327-53-3 Arsenic(III) oxide
Prop 65 - Developmental toxicity
1327-53-3 Arsenic(III) oxide
Prop 65 - Developmental toxicity, female
Substance is not listed.
Prop 65 - Developmental toxicity, male
Substance is not listed.
Information about limitation of use:
Workers are not allowed to be exposed to this hazardous material. Exceptions can be made by the authorities in certain cases.
For use only by technically qualified individuals.
This product is subject to the reporting requirements of section 313 of the Emergency Planning and Community Right to Know Act of 1986 and 40CFR372.
Other regulations, limitations and prohibitive regulations
Substance of Very High Concern (SVHC) according to the REACH Regulations (EC) No. 1907/2006.
This substance is included in the Candidate List of Substances of Very High Concern (
SVHC) according to Regulation (EC) No. 1907/2006 (REACH).
The conditions of restrictions according to Article 67 and Annex XVII of the Regulation (EC) No 1907/2006 (REACH) for the manufacturing, placing on the market and use must be observed.
Substance is not listed.
Annex XIV of the REACH Regulations (requiring Authorisation for use)
Substance is listed.
Chemical safety assessment:
A Chemical Safety Assessment has not been carried out.


16. OTHER INFORMATION

Safety Data Sheet according to Regulation (EC) No. 1907/2006 (REACH). The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. American Elements shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale. COPYRIGHT 1997-2016 AMERICAN ELEMENTS. LICENSED GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY.

About Arsenic Oxide Nanoparticles / Nanopowder

Arsenic Oxide (As2O3) Nanopowder or Nanoparticles, nanodots or nanocrystals are spherical or faceted high surface area oxide magnetic nanostructured particles. Nanoscale Arsenic Oxide Particles are typically 20-80 nanometers (nm) with specific surface area (SSA) in the 10 - 50 m2/g range and also available in with an average particle size of 100 nm range with a specific surface area of approximately 7- 10 m2/g. Nano Arsenic Oxide Particles are also available in ultra high purity and high purity, transparent, and coated and dispersed forms. They are also available as a nanofluid through the AE Nanofluid production group. Nanofluids are generally defined as suspended nanoparticles in solution either using surfactant or surface charge technology. Nanofluid dispersion and coating selection technical guidance is also available. Other nanostructures include nanorods, nanowhiskers, nanohorns, nanopyramids and other nanocomposites. Surface functionalized nanoparticles allow for the particles to be preferentially adsorbed at the surface interface using chemically bound polymers.

Arsenic Oxide Nanoparticles / Nanopowder Synonyms

Arsenic trioxide, Tricyclo[3.3.1.13,7]tetraarsoxane, Arsenous acid, White arsenic, Crude arsenic, Arsenic(III) oxide, Arsenious oxide, Diarsenic oxide, Arsenic(3+); oxygen(2-), Diarsenic trioxide, Tricyclo[3.3.1.13,7]tetraarsoxane, Arsenous oxide anhydride, Diarsenic trioxide, arsenic trioxide, Arseni trioxydum, Trisenox, Arsenolite, Arsentrioxide, Claudetite, Arsenic sesquioxide

Arsenic Oxide Nanoparticles / Nanopowder Chemical Identifiers

Linear Formula

As2O3

Pubchem CID

261004

MDL Number

MFCD00003433

EC No.

215-481-4

Beilstein Registry No.

N/A

IUPAC Name

Arsenic(3+); oxygen(2-)

SMILES

O1[As]3O[As]2O[As](O[As]1O2)O3

InchI Identifier

InChI=1S/As4O6/c5-1-6-3-8-2(5)9-4(7-1)10-3

InchI Key

KTTMEOWBIWLMSE-UHFFFAOYSA-N

Packaging Specifications

Typical bulk packaging includes palletized plastic 5 gallon/25 kg. pails, fiber and steel drums to 1 ton super sacks in full container (FCL) or truck load (T/L) quantities. Research and sample quantities and hygroscopic, oxidizing or other air sensitive materials may be packaged under argon or vacuum. Shipping documentation includes a Certificate of Analysis and Safety Data Sheet (SDS). Solutions are packaged in polypropylene, plastic or glass jars up to palletized 440 gallon liquid totes, and 36,000 lb. tanker trucks.

Related Elements

See more Arsenic products. Arsenic (atomic symbol: As, atomic number: 33) is a Block P, Group 15, Period 4 element with an atomic radius of 74.92160. Arsenic Bohr ModelThe number of electrons in each of arsenic's shells is 2, 8, 18, 5 and its electron configuration is [Ar] 3d10 4s2 4p3. The arsenic atom has a radius of 119 pm and a Van der Waals radius of 185 pm. Arsenic was discovered in the early Bronze Age, circa 2500 BC. It was first isolated by Albertus Magnus in 1250 AD. In its elemental form, arsenic is a metallic grey, brittle, crystalline, semimetallic solid. Elemental ArsenicArsenic is found in numerous minerals including arsenolite (As2O3), arsenopyrite (FeAsS), loellingite (FeAs2), orpiment (As2S3), and realgar (As4S4). Arsenic has numerous applications as a semiconductor and other electronic applications as indium arsenide, silicon arsenide and tin arsenide. Arsenic is finding increasing uses as a doping agent in solid-state devices such as transistors.

Recent Research

Autologous hematopoietic cell transplantation for acute promyelocytic leukemia in second complete remission: outcomes before and after the introduction of arsenic trioxide., Yanada, Masamitsu, Yano Shingo, Kanamori Heiwa, Gotoh Moritaka, Emi Nobuhiko, Watakabe Kyoko, Kurokawa Mineo, Nishikawa Akinori, Mori Takehiko, Tomita Naoto, et al. , Leuk Lymphoma, 2017 May, Volume 58, Issue 5, p.1061-1067, (2017)

Dihydroartemisinin Sensitizes Human Lung Adenocarcinoma A549 Cells to Arsenic Trioxide via Apoptosis., Chen, Hongyu, Gu Shiyan, Dai Huangmei, Li Xinyang, and Zhang Zunzhen , Biol Trace Elem Res, 2017 Mar 06, (2017)

Removal of arsenic(III) from water by magnetic binary oxide particles (MBOP): Experimental studies on fixed bed column., Dhoble, Rajesh M., Maddigapu Pratap Reddy, Rayalu Sadhana S., Bhole A G., Dhoble Ashwinkumar S., and Dhoble Shubham R. , J Hazard Mater, 2017 Jan 15, Volume 322, Issue Pt B, p.469-478, (2017)

Facile synthesis of high-thermostably ordered mesoporous TiO2/SiO2 nanocomposites: An effective bifunctional candidate for removing arsenic contaminations., Wang, Yubao, Xing Zipeng, Li Zhenzi, Wu Xiaoyan, Wang Guofeng, and Zhou Wei , J Colloid Interface Sci, 2017 Jan 1, Volume 485, p.32-38, (2017)

In-situ mobilization and transformation of iron oxides-adsorbed arsenate in natural groundwater., Zhang, Di, Guo Huaming, Xiu Wei, Ni Ping, Zheng Hao, and Wei Cao , J Hazard Mater, 2017 Jan 05, Volume 321, p.228-237, (2017)

Synthesis and characterization of hybrid iron oxide silicates for selective removal of arsenic oxyanions from contaminated water., El-Moselhy, Medhat Mohamed, Ates Ayten, and Çelebi Ahmet , J Colloid Interface Sci, 2017 Feb 15, Volume 488, p.335-347, (2017)

Effects of manganese oxide-modified biochar composites on arsenic speciation and accumulation in an indica rice (Oryza sativa L.) cultivar., Yu, Zhihong, Qiu Weiwen, Wang Fei, Lei Ming, Wang Di, and Song Zhengguo , Chemosphere, 2017 Feb, Volume 168, p.341-349, (2017)

Equilibrium and kinetics study on removal of arsenate ions from aqueous solution by CTAB/TiO2 and starch/CTAB/TiO2 nanoparticles: a comparative study., Gogoi, Pankaj, Dutta Debasish, and Maji Tarun Kr , J Water Health, 2017 Feb, Volume 15, Issue 1, p.58-71, (2017)

Tuning DNA adsorption affinity and density on metal oxide and phosphate for improved arsenate detection., Lopez, Anand, Zhang Yifei, and Liu Juewen , J Colloid Interface Sci, 2017 05 01, Volume 493, p.249-256, (2017)

Synthesis and characterization of ZnO:CeO2:nanocellulose:PANI bionanocomposite. A bimodal agent for arsenic adsorption and antibacterial action., Nath, B K., Chaliha C, Kalita E, and Kalita M C. , Carbohydr Polym, 2016 Sep 5, Volume 148, p.397-405, (2016)

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