Dual-responsive electrochemical immunosensor for detection of insulin based on dual-functional zinc silicate spheres-palladium nanoparticles.

Title Dual-responsive electrochemical immunosensor for detection of insulin based on dual-functional zinc silicate spheres-palladium nanoparticles.
Authors Y. Li; L. Tian; L. Liu; M.Saddam Khan; G. Zhao; D. Fan; W. Cao; Q. Wei
Journal Talanta
DOI 10.1016/j.talanta.2017.11.037
Abstract

In this study, described an electrochemical immunoassay for insulin that is based on the use of zinc silicate spheres loaded with palladium nanoparticles (Zn2SiO4-PdNPs) that act as dual-function labels. The Zn2SiO4-PdNPs display high electrocatalytic activity towards the reduction of H2O2 and high sensitivity in chronoamperometry. The Zn2SiO4-PdNPs decrease the electron transfer rate between the electrolyte and the surface of the electrode, which can increase the changed current and enhance the sensitivity of the immunosensor as detected by square wave voltammetry (SWV). Electrodeposited gold is used as the matrix material. The icosahedral gold nanocrystals are coated with the primary antibodies formed a 3D mode to against abundant of insulin. Under optimal conditions, the assay has a linear response in the 0.1pgmL-1 to 50ngmL-1 insulin concentration range, and the limit of detection of the SWV and CA methods are 0.25 fg mL-1 and 80 fg mL-1, respectively. Moreover, the immunosensor holds an outstanding analytical performance for the insulin detection and has promising potential in clinical diagnosis.

Citation Y. Li; L. Tian; L. Liu; M.Saddam Khan; G. Zhao; D. Fan; W. Cao; Q. Wei.Dual-responsive electrochemical immunosensor for detection of insulin based on dual-functional zinc silicate spheres-palladium nanoparticles.. Talanta. 2018;179:420425. doi:10.1016/j.talanta.2017.11.037

Related Elements

Palladium

Palladium Bohr ModelSee more Palladium products. Palladium (atomic symbol: Pd, atomic number: 46) is a Block D, Group 10, Period 5 element with an atomic weight of 106.42. The number of electrons in each of palladium's shells is 2, 8, 18, 18 and its electron configuration is [Kr] 4d10. The palladium atom has a radius of 137 pm and a Van der Waals radius of 202 pm. In its elemental form, palladium has a silvery white appearance. Palladium is a member of the platinum group of metals (along with platinum, rhodium, ruthenium, iridium and osmium). Elemental PalladiumPalladium has the lowest melting point and is the least dense of the group. Palladium can be found as a free metal and alloyed with other platinum-group metals. Nickel-copper deposits are the main commercial source of palladium. Palladium was discovered and first isolated by William Hyde Wollaston in 1803. Its name is derived from the asteroid Pallas.

Silicon

See more Silicon products. Silicon (atomic symbol: Si, atomic number: 14) is a Block P, Group 14, Period 3 element with an atomic weight of 28.085. Silicon Bohr MoleculeThe number of electrons in each of Silicon's shells is 2, 8, 4 and its electron configuration is [Ne] 3s2 3p2. The silicon atom has a radius of 111 pm and a Van der Waals radius of 210 pm. Silicon was discovered and first isolated by Jöns Jacob Berzelius in 1823. Silicon makes up 25.7% of the earth's crust, by weight, and is the second most abundant element, exceeded only by oxygen. The metalloid is rarely found in pure crystal form and is usually produced from the iron-silicon alloy ferrosilicon. Elemental SiliconSilica (or silicon dioxide), as sand, is a principal ingredient of glass, one of the most inexpensive of materials with excellent mechanical, optical, thermal, and electrical properties. Ultra high purity silicon can be doped with boron, gallium, phosphorus, or arsenic to produce silicon for use in transistors, solar cells, rectifiers, and other solid-state devices which are used extensively in the electronics industry.The name Silicon originates from the Latin word silex which means flint or hard stone.

Zinc

See more Zinc products. Zinc (atomic symbol: Zn, atomic number: 30) is a Block D, Group 12, Period 4 element with an atomic weight of 65.38. The number of electrons in each of zinc's shells is 2, 8, 18, 2, and its electron configuration is [Ar] 3d10 4s2. Zinc Bohr ModelThe zinc atom has a radius of 134 pm and a Van der Waals radius of 210 pm. Zinc was discovered by Indian metallurgists prior to 1000 BC and first recognized as a unique element by Rasaratna Samuccaya in 800. Zinc was first isolated by Andreas Marggraf in 1746. In its elemental form, zinc has a silver-gray appearance. It is brittle at ordinary temperatures but malleable at 100 °C to 150 °C.Elemental Zinc It is a fair conductor of electricity, and burns in air at high red producing white clouds of the oxide. Zinc is mined from sulfidic ore deposits. It is the 24th most abundant element in the earth's crust and the fourth most common metal in use (after iron, aluminum, and copper). The name zinc originates from the German word "zin," meaning tin.

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