Establishment of experimental autoimmune prostatitis model by Tpeptide in aluminium hydroxide adjuvant.

Title Establishment of experimental autoimmune prostatitis model by Tpeptide in aluminium hydroxide adjuvant.
Authors L. Zhang; A.U. Ihsan; Y. Cao; Y. Cheng; X. Zhou
Journal Andrologia
DOI 10.1111/and.12922
Abstract

A mouse model was developed to simulate the clinical features of chronic prostatitis/chronic pelvic pain syndrome using peptide (T). Forty C57BL/6 mice were divided into four groups of 10 mice each, averagely and randomly. Tplus aluminium hydroxide adjuvant group was given subcutaneous injection with the emulsion mixture of Tand aluminium hydroxide adjuvant, the Tgroup with T, the aluminium hydroxide adjuvant group with aluminium hydroxide adjuvant and the normal control group with 0.9/% NaCl solution. Haematoxylin andeosin staining was used to observe the inflammation of the prostate. Plasma levels of TNF-? and CRP were detected by ELISA kit. The expression of IL-1?in the prostate was investigated by immunohistochemistry. The statistical differences between the groups were compared by t test. Histopathological analyses demonstrated that prostate lesions were most severe in the group immunised with Tplus aluminium hydroxide adjuvant. Plasma levels of TNF-? and CRP were statistically elevated compared with control groups. The expression levels of IL-1? in the prostate were more obvious than control groups. Tin aluminium hydroxide adjuvant subcutaneous injection could successfully set up experimental autoimmune prostatitis in C57BL/6 mice. This murine model would be greatly beneficial to further comprehend the aetiology, pathogenesis and explicit treatment of CP/CPPS.

Citation L. Zhang; A.U. Ihsan; Y. Cao; Y. Cheng; X. Zhou.Establishment of experimental autoimmune prostatitis model by Tpeptide in aluminium hydroxide adjuvant.. Andrologia. 2018;50(3). doi:10.1111/and.12922

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See more Aluminum products. Aluminum (or Aluminium) (atomic symbol: Al, atomic number: 13) is a Block P, Group 13, Period 3 element with an atomic weight of 26.9815386. It is the third most abundant element in the earth's crust and the most abundant metallic element. Aluminum Bohr Model Aluminum's name is derived from alumina, the mineral from which Sir Humphrey Davy attempted to refine it from in 1812. Aluminum was first predicted by Antoine Lavoisier 1787 and first isolated by Hans Christian Øersted in 1825. Aluminum is a silvery gray metal that possesses many desirable characteristics. It is light, nonmagnetic and non-sparking. It stands second among metals in the scale of malleability, and sixth in ductility. It is extensively used in many industrial applications where a strong, light, easily constructed material is needed. Elemental AluminumAlthough it has only 60% of the electrical conductivity of copper, it is used in electrical transmission lines because of its light weight. Pure aluminum is soft and lacks strength, but alloyed with small amounts of copper, magnesium, silicon, manganese, or other elements, it imparts a variety of useful properties.

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