Europium-doped mesoporous silica nanosphere as an immune-modulating osteogenesis/angiogenesis agent.

Title Europium-doped mesoporous silica nanosphere as an immune-modulating osteogenesis/angiogenesis agent.
Authors M. Shi; L. Xia; Z. Chen; F. Lv; H. Zhu; F. Wei; S. Han; J. Chang; Y. Xiao; C. Wu
Journal Biomaterials
DOI 10.1016/j.biomaterials.2017.08.027

Although much research has gone into the design of nanomaterials, inflammatory response still impedes the capacity of nanomaterial-induced tissue regeneration. In-situ incorporation of nutrient elements in silica-based biomaterials has emerged as a new option to endow the nanomaterials modulating biological reactions. In this work, europium-doped mesoporous silica nanospheres (Eu-MSNs) were successfully synthesized via a one-pot method. The nanospheres (size of 280-300 nm) possess uniformly spherical morphology and mesoporous structure, and well distributed Eu elements. The nanospheres show distinct fluorescent property at 615 nm for potential bio-labeling. Noticeably, the Eu-MSNs stimulate pro-inflammatory response of macrophages and induce a modulated immune microenvironment, which further activates the osteogenic differentiation of bone marrow stromal cells (BMSCs) as well as angiogenic activity of human umbilical vein endothelial cells (HUVECs). During the process, osteogenesis-related genes (e.g. ALP, OCN, OPN and COL-I) of BMSCs, and angiogenesis-related genes (e.g. CD31, MMP9, VEGFR1/2, and PDGFR?/?) of HUVECs were significantly upregulated by Eu-MSNs modulating immune environment of macrophages. The in vivo study further demonstrated that the Eu-MSNs could not only stimulate osteogenesis by accelerating the new bone formation at critical-sized cranial defect site, but also support the blood vessel formation as well as collagen deposition and re-epithelialization at chronic skin wound sites, showing an improved angiogenesis activity when comparing with MSNs alone. Given the easy handling characteristics and extensive application potential, the results suggest that Eu-MSNs could be used as immunity-modulated osteogenesis/angiogenesis agent for skin and bone regeneration.

Citation M. Shi; L. Xia; Z. Chen; F. Lv; H. Zhu; F. Wei; S. Han; J. Chang; Y. Xiao; C. Wu.Europium-doped mesoporous silica nanosphere as an immune-modulating osteogenesis/angiogenesis agent.. Biomaterials. 2017;144:176187. doi:10.1016/j.biomaterials.2017.08.027

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See more Europium products. Europium (atomic symbol: Eu, atomic number: 63) is a Block F, Group 3, Period 6 element with an atomic radius of 151.964. Europium Bohr ModelThe number of electrons in each of Europium's shells is 2, 8, 18, 25, 8, 2 and its electron configuration is [Xe]4f7 6s2. The europium atom has an atomic radius of 180 pm and a Van der Waals radius of 233 pm. Europium was discovered by Eugène-Anatole Demarçay in 1896, however, he did not isolate it until 1901. Europium was named after the continent of Europe.Elemental Europium Picture Europium is a member of the lanthanide or rare earth series of metals. In its elemental form, it has a silvery-white appearance but it is rarely found without oxide discoloration. Europium is found in many minerals including bastnasite, monazite, xenotime and loparite. It is not found in nature as a free element.


See more Silicon products. Silicon (atomic symbol: Si, atomic number: 14) is a Block P, Group 14, Period 3 element with an atomic weight of 28.085. Silicon Bohr MoleculeThe number of electrons in each of Silicon's shells is 2, 8, 4 and its electron configuration is [Ne] 3s2 3p2. The silicon atom has a radius of 111 pm and a Van der Waals radius of 210 pm. Silicon was discovered and first isolated by Jöns Jacob Berzelius in 1823. Silicon makes up 25.7% of the earth's crust, by weight, and is the second most abundant element, exceeded only by oxygen. The metalloid is rarely found in pure crystal form and is usually produced from the iron-silicon alloy ferrosilicon. Elemental SiliconSilica (or silicon dioxide), as sand, is a principal ingredient of glass, one of the most inexpensive of materials with excellent mechanical, optical, thermal, and electrical properties. Ultra high purity silicon can be doped with boron, gallium, phosphorus, or arsenic to produce silicon for use in transistors, solar cells, rectifiers, and other solid-state devices which are used extensively in the electronics industry.The name Silicon originates from the Latin word silex which means flint or hard stone.

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