Evaluation of folic acid tagged aminated starch/ZnO coated iron oxide nanoparticles as targeted curcumin delivery system.

Title Evaluation of folic acid tagged aminated starch/ZnO coated iron oxide nanoparticles as targeted curcumin delivery system.
Authors C. Saikia; M.K. Das; A. Ramteke; T.K. Maji
Journal Carbohydr Polym
DOI 10.1016/j.carbpol.2016.09.087
Abstract

The role of 'superparamagnetic iron oxide nanoparticles' has gained considerable interest in various biomedical applications. However extensive researches are still going on to modify the nanoparticle size, surface properties etc. in order to get full benefit of the material. In this study, iron oxide nanoparticles have been modified with folic acid tagged aminated starch/ZnO coating to formulate a targeted drug delivery system. The nanoparticles were characterized by Fourier Transform Infra-red Spectroscopy, X-ray Diffraction, Scanning Electron Microscopy and Transmission Electron Microscopy. Both the swelling and in vitro drug release was performed in both acidic and alkaline pH. The cytotoxicity of the drug loaded nanoparticles was analysed by MTT assay in human lymphocytes, HepG2 and MCF7 cell lines. The cell uptake efficiencies and Reactive Oxygen Species generation with the drug loaded nanoparticles was estimated in HepG2 cell lines. The uptake capacity of fluorescein isothiocyanate tagged nanoparticles was assessed by fluorescence microscope.

Citation C. Saikia; M.K. Das; A. Ramteke; T.K. Maji.Evaluation of folic acid tagged aminated starch/ZnO coated iron oxide nanoparticles as targeted curcumin delivery system.. Carbohydr Polym. 2017;157:391399. doi:10.1016/j.carbpol.2016.09.087

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Iron

See more Iron products. Iron (atomic symbol: Fe, atomic number: 26) is a Block D, Group 8, Period 4 element with an atomic weight of 55.845. The number of electrons in each of Iron's shells is 2, 8, 14, 2 and its electron configuration is [Ar] 3d6 4s2. Iron Bohr ModelThe iron atom has a radius of 126 pm and a Van der Waals radius of 194 pm. Iron was discovered by humans before 5000 BC. In its elemental form, iron has a lustrous grayish metallic appearance. Iron is the fourth most common element in the Earth's crust and the most common element by mass forming the earth as a whole. Iron is rarely found as a free element, since it tends to oxidize easily; it is usually found in minerals such as magnetite, hematite, goethite, limonite, or siderite.Elemental Iron Though pure iron is typically soft, the addition of carbon creates the alloy known as steel, which is significantly stronger.

Zinc

See more Zinc products. Zinc (atomic symbol: Zn, atomic number: 30) is a Block D, Group 12, Period 4 element with an atomic weight of 65.38. The number of electrons in each of zinc's shells is 2, 8, 18, 2, and its electron configuration is [Ar] 3d10 4s2. Zinc Bohr ModelThe zinc atom has a radius of 134 pm and a Van der Waals radius of 210 pm. Zinc was discovered by Indian metallurgists prior to 1000 BC and first recognized as a unique element by Rasaratna Samuccaya in 800. Zinc was first isolated by Andreas Marggraf in 1746. In its elemental form, zinc has a silver-gray appearance. It is brittle at ordinary temperatures but malleable at 100 °C to 150 °C.Elemental Zinc It is a fair conductor of electricity, and burns in air at high red producing white clouds of the oxide. Zinc is mined from sulfidic ore deposits. It is the 24th most abundant element in the earth's crust and the fourth most common metal in use (after iron, aluminum, and copper). The name zinc originates from the German word "zin," meaning tin.

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