Grignard Reagents on a Tab: Direct Magnesium Insertion under Flow Conditions.

Title Grignard Reagents on a Tab: Direct Magnesium Insertion under Flow Conditions.
Authors L. Huck; A. de la Hoz; A. Díaz-Ortiz; J. Alcázar
Journal Org Lett
DOI 10.1021/acs.orglett.7b01590
Abstract

An on-demand preparation of organomagnesium reagents is presented using a new flow protocol. The risks associated with the activation of magnesium are circumvented by a new on-column initiation procedure. Required amounts of solutions with a precise titration were obtained. Telescoped flow or batch reactions allow access to a diverse set of functional groups.

Citation L. Huck; A. de la Hoz; A. Díaz-Ortiz; J. Alcázar.Grignard Reagents on a Tab: Direct Magnesium Insertion under Flow Conditions.. Org Lett. 2017. doi:10.1021/acs.orglett.7b01590

Related Elements

Magnesium

Magnesium Bohr ModelSee more Magnesium products. Magnesium (atomic symbol: Mg, atomic number: 12) is a Block S, Group 2, Period 3 element with an atomic mass of 24.3050. The number of electrons in each of Magnesium's shells is [2, 8, 2] and its electron configuration is [Ne] 3s2. The magnesium atom has a radius of 160 pm and a Van der Waals radius of 173 pm. Magnesium was discovered by Joseph Black in 1775 and first isolated by Sir Humphrey Davy in 1808. Magnesium is the eighth most abundant element in the earth's crust and the fourth most common element in the earth as a whole. Elemental MagnesiumIn its elemental form, magnesium has a shiny grey metallic appearance and is an extremely reactive. It is can be found in minerals such as brucite, carnallite, dolomite, magnesite, olivine and talc. Commercially, magnesium is primarily used in the creation of strong and lightweight aluminum-magnesium alloys, which have numerous advantages in industrial applications. The name "Magnesium" originates from a Greek district in Thessaly called Magnesia.

Related Forms & Applications