High-Precision Photothermal Ablation using Biocompatible Palladium Nanoparticles and Laser Scanning Microscopy.

Title High-Precision Photothermal Ablation using Biocompatible Palladium Nanoparticles and Laser Scanning Microscopy.
Authors B.Rubio Ruiz; A. Perez-Lopez; T. Bray; M. Lee; A. Serrels; M. Prieto; M. Arruebo; N.O. Carragher; V. Sebastian; A. Unciti-Broceta
Journal ACS Appl Mater Interfaces
DOI 10.1021/acsami.7b17282
Abstract

Herein we report a straightforward method for the scalable preparation of Pd nanoparticles (Pd-NPs) with reduced inherent cytotoxicity and high photothermal conversion capacity. These Pd-NPs are rapidly taken up by cells and able to kill labelled cancer cells upon short exposure to near infrared (NIR) light. Following cell treatment with Pd-NPs, ablated areas were patterned with high precision by laser scanning microscopy, allowing to perform cell migration assays with unprecedented accuracy. Using coherent Raman microscopy, cells containing Pd-NPs were simultaneously ablated and imaged. This novel methodology was combined with intravital imaging to mediate micro-ablation of cancerous tissue in tumour xenografts in mice.

Citation B.Rubio Ruiz; A. Perez-Lopez; T. Bray; M. Lee; A. Serrels; M. Prieto; M. Arruebo; N.O. Carragher; V. Sebastian; A. Unciti-Broceta.High-Precision Photothermal Ablation using Biocompatible Palladium Nanoparticles and Laser Scanning Microscopy.. ACS Appl Mater Interfaces. 2018. doi:10.1021/acsami.7b17282

Related Elements

Palladium

46 Pd 106.420000000 Palladium

Palladium Bohr ModelSee more Palladium products. Palladium (atomic symbol: Pd, atomic number: 46) is a Block D, Group 10, Period 5 element with an atomic weight of 106.42. The number of electrons in each of palladium's shells is 2, 8, 18, 18 and its electron configuration is [Kr] 4d10. The palladium atom has a radius of 137 pm and a Van der Waals radius of 202 pm. In its elemental form, palladium has a silvery white appearance. Palladium is a member of the platinum group of metals (along with platinum, rhodium, ruthenium, iridium and osmium). Elemental PalladiumPalladium has the lowest melting point and is the least dense of the group. Palladium can be found as a free metal and alloyed with other platinum-group metals. Nickel-copper deposits are the main commercial source of palladium. Palladium was discovered and first isolated by William Hyde Wollaston in 1803. Its name is derived from the asteroid Pallas.

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Metals Nanomaterials
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