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Hydroxyapatite Nanoparticles / Nanopowder

CAS #:

Linear Formula:

[Ca5(OH)(PO4)3]x

MDL Number:

MFCD00010904

EC No.:

235-330-6

ORDER

PRODUCT Product Code ORDER SAFETY DATA TECHNICAL DATA
>97% Hydroxyapatite Nanopowder
CA-PATOH-017-NP
Pricing > SDS > Data Sheet >
98% Hydroxyapatite Nanopowder
CA-PATOH-018-NP
Pricing > SDS > Data Sheet >
99% Hydroxyapatite Nanopowder
CA-PATOH-02-NP
Pricing > SDS > Data Sheet >
Question? Ask an American Elements EngineerWHOLESALE/SKU 0000-742-13230

Hydroxyapatite Nanoparticles / Nanopowder Properties

Compound Formula

HCa5O13P3

Molecular Weight

502.31

Appearance

Crystalline powder

Melting Point

1100 °C

Boiling Point

N/A

Exact Mass

501.675955

Monoisotopic Mass

501.675955

Hydroxyapatite Nanoparticles / Nanopowder Health & Safety Information

Signal Word Warning
Hazard Statements H315-H319-H335
Hazard Codes Xi
Risk Codes 36/37/38
Safety Statements 26
RTECS Number N/A
Transport Information N/A
WGK Germany 3
GHS Pictograms

View and Print SDS

SAFETY DATA SHEET

Date Accessed: 05/24/2017
Date Revised: 05/15/2015

SECTION 1. IDENTIFICATION

Product Name: Hydroxyapatite Nanoparticles / Nanopowder

Product Number: All applicable American Elements product codes, e.g. CA-PATOH-017-NP , CA-PATOH-018-NP , CA-PATOH-02-NP

CAS #: 1306-06-5

Relevant identified uses of the substance: Scientific research and development

Supplier details:
American Elements
1093 Broxton Ave. Suite 2000
Los Angeles, CA 90024
Tel: +1 310-208-0551
Fax: +1 310-208-0351

Emergency telephone number:
Domestic, North America +1 800-424-9300
International +1 703-527-3887


SECTION 2. HAZARDS IDENTIFICATION

Classification of the substance or mixture in accordance with 29 CFR 1910 (OSHA HCS)
GHS07
Skin Irrit. 2 H315 Causes skin irritation.
Eye Irrit. 2A H319 Causes serious eye irritation.
Hazards not otherwise classified
No information known.
Label elements
GHS label elements
The product is classified and labeled in accordance with 29 CFR 1910 (OSHA HCS)
Hazard pictograms

Exclamation Mark - GHS07

GHS07
Signal word
Warning
Hazard statements
H315 Causes skin irritation.
H319 Causes serious eye irritation.
Precautionary statements
P280
Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P362
Take off contaminated clothing.
P321
Specific treatment (see on this label).
P332+P313
If skin irritation occurs: Get medical advice/attention.
P337+P313
If eye irritation persists: Get medical advice/attention.
WHMIS classification
Not controlled
Classification system
HMIS ratings (scale 0-4)
(Hazardous Materials Identification System)
Health (acute effects) = 1
Flammability = 0
Physical Hazard = 1
Other hazards
Results of PBT and vPvB assessment
PBT:
Not applicable.
vPvB:
Not applicable.


SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS

Chemical characterization: Mixtures
Dangerous components:
1306-06-5 Calcium phosphate tribasic (Hydroxyapatite)
Skin Irrit. 2, H315; Eye Irrit. 2A, H319; STOT SE 3, H335
10.0%
Additional information
None known.
Non-Hazardous Ingredients
7732-18-5 Water
90.0%


SECTION 4. FIRST AID MEASURES

Description of first aid measures
After inhalation
Supply fresh air. If required, provide artificial respiration. Keep patient warm.
Seek immediate medical advice.
After skin contact
Immediately wash with water and soap and rinse thoroughly.
Seek immediate medical advice.
After eye contact
Rinse opened eye for several minutes under running water. Then consult a doctor.
After swallowing
Seek medical treatment.
Information for doctor
Most important symptoms and effects, both acute and delayed
No further relevant information available.
Indication of any immediate medical attention and special treatment needed
No further relevant information available.


SECTION 5. FIREFIGHTING MEASURES

Extinguishing media
Suitable extinguishing agents
Product is not flammable. Use fire-fighting measures that suit the surrounding fire.
Special hazards arising from the substance or mixture
If this product is involved in a fire, the following can be released:
Calcium oxide
Phosphorus oxides
Advice for firefighters
Protective equipment:
Wear self-contained respirator.
Wear fully protective impervious suit.


SECTION 6. ACCIDENTAL RELEASE MEASURES

Personal precautions, protective equipment and emergency procedures
Wear protective equipment. Keep unprotected persons away.
Ensure adequate ventilation
Environmental precautions:
Do not allow product to reach sewage system or any water course.
Methods and material for containment and cleaning up:
Absorb with liquid-binding material (sand, diatomite, acid binders, universal binders, sawdust).
Prevention of secondary hazards:
No special measures required.
Reference to other sections
See Section 7 for information on safe handling
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.


SECTION 7. HANDLING AND STORAGE

Handling
Precautions for safe handling
Keep container tightly sealed.
Ensure good ventilation at the workplace.
Information about protection against explosions and fires:
The product is not flammable
Conditions for safe storage, including any incompatibilities
Storage
Requirements to be met by storerooms and receptacles:
Refrigerate
Information about storage in one common storage facility:
Protect from heat.
Water reacts with many metals to give hydrogen, often violently. Water is also incompatible with many reactive organic and inorganic chemicals.
Further information about storage conditions:
Keep container tightly sealed.
Refrigerate
Specific end use(s)
No further relevant information available.


SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION

Additional information about design of technical systems:
Properly operating chemical fume hood designed for hazardous chemicals and having an average face velocity of at least 100 feet per minute.
Control parameters
Components with limit values that require monitoring at the workplace:
The product does not contain any relevant quantities of materials with critical values that have to be monitored at the workplace.
Additional information:
No data
Exposure controls
Personal protective equipment
General protective and hygienic measures
The usual precautionary measures for handling chemicals should be followed.
Keep away from foodstuffs, beverages and feed.
Remove all soiled and contaminated clothing immediately.
Wash hands before breaks and at the end of work.
Maintain an ergonomically appropriate working environment.
Breathing equipment:
Use suitable respirator when high concentrations are present.
Protection of hands:
Impervious gloves
Check protective gloves prior to each use for their proper condition.
The selection of suitable gloves not only depends on the material, but also on quality. Quality will vary from manufacturer to manufacturer.
Penetration time of glove material (in minutes)
Not determined
Eye protection:
Safety glasses
Body protection:
Protective work clothing.


SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES

Information on basic physical and chemical properties
General Information
Appearance:
Form: Dispersion
Odor: Not determined
Odor threshold: Not determined.
pH-value: Not determined.
Change in condition
Melting point/Melting range: Not determined
Boiling point/Boiling range: Not determined
Sublimation temperature / start: Not determined
Flammability (solid, gaseous)
Not determined.
Ignition temperature: Not determined
Decomposition temperature: Not determined
Auto igniting: Product is not selfigniting.
Danger of explosion: Not determined.
Explosion limits:
Lower: Not determined
Upper: Not determined
Vapor pressure at 20 °C (68 °F): 23 hPa (17 mm Hg)
Density: Not determined
Relative density
Not determined.
Vapor density
Not determined.
Evaporation rate
Not determined.
Solubility in / Miscibility with Water: Not miscible or difficult to mix
Partition coefficient (n-octanol/water): Not determined.
Viscosity:
dynamic: Not determined.
kinematic: Not determined.
Solvent content:
Organic solvents:
0.0 %
Solids content:
10.0 %
Other information
No further relevant information available.


SECTION 10. STABILITY AND REACTIVITY

Reactivity
No information known.
Chemical stability
Stable under recommended storage conditions.
Thermal decomposition / conditions to be avoided:
Decomposition will not occur if used and stored according to specifications.
Possibility of hazardous reactions
Water reacts violently with alkali metals.
Water reacts with many metals to give hydrogen, often violently. Water is also incompatible with many reactive organic and inorganic chemicals.
Conditions to avoid
No further relevant information available.
Incompatible materials:
Heat
Hazardous decomposition products:
Calcium oxide
Phosphorus oxides (e.g. P2O5)


SECTION 11. TOXICOLOGICAL INFORMATION

Information on toxicological effects
Acute toxicity:
No effects known.
LD/LC50 values that are relevant for classification:
No data
Skin irritation or corrosion:
May cause irritation
Eye irritation or corrosion:
May cause irritation
Sensitization:
No sensitizing effects known.
Germ cell mutagenicity:
No effects known.
Carcinogenicity:
No classification data on carcinogenic properties of this material is available from the EPA, IARC, NTP, OSHA or ACGIH.
Reproductive toxicity:
No effects known.
Specific target organ system toxicity - repeated exposure:
No effects known.
Specific target organ system toxicity - single exposure:
No effects known.
Aspiration hazard:
No effects known.
Subacute to chronic toxicity:
No effects known.
Additional toxicological information:
To the best of our knowledge the acute and chronic toxicity of this substance is not fully known.


SECTION 12. ECOLOGICAL INFORMATION

Toxicity
Aquatic toxicity:
No further relevant information available.
Persistence and degradability
No further relevant information available.
Bioaccumulative potential
No further relevant information available.
Mobility in soil
No further relevant information available.
Additional ecological information:
General notes:
Do not allow undiluted product or large quantities to reach ground water, water course or sewage system.
Avoid transfer into the environment.
Results of PBT and vPvB assessment
PBT:
Not applicable.
vPvB:
Not applicable.
Other adverse effects
No further relevant information available.


SECTION 13. DISPOSAL CONSIDERATIONS

Waste treatment methods
Recommendation
Consult state, local or national regulations to ensure proper disposal.
Uncleaned packagings:
Recommendation:
Disposal must be made according to official regulations.


SECTION 14. TRANSPORT INFORMATION

UN-Number
DOT, ADN, IMDG, IATA
Not applicable
UN proper shipping name
DOT, ADN, IMDG, IATA
Not applicable
Transport hazard class(es)
DOT, ADR, ADN, IMDG, IATA
Class
Not applicable
Packing group
DOT, IMDG, IATA
Not applicable
Environmental hazards:
Marine pollutant (IMDG):
No
Special precautions for user
Not applicable.
Transport in bulk according to Annex II of MARPOL73/78 and the IBC Code
Not applicable.
Transport/Additional information:
DOT
Marine Pollutant (DOT):
No


SECTION 15. REGULATORY INFORMATION

Safety, health and environmental regulations/legislation specific for the substance or mixture
GHS label elements
The product is classified and labeled in accordance with 29 CFR 1910 (OSHA HCS)
Hazard pictograms
GHS07
Signal word
Warning
Hazard statements
H315 Causes skin irritation.
H319 Causes serious eye irritation.
Precautionary statements
P280
Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P362
Take off contaminated clothing.
P321
Specific treatment (see on this label).
P332+P313
If skin irritation occurs: Get medical advice/attention.
P337+P313
If eye irritation persists: Get medical advice/attention.
National regulations
All components of this product are listed on the Canadian Domestic Substances List (DSL).
This product is not listed in the U.S. Environmental Protection Agency Toxic Substances Control Act Chemical Substance Inventory. Use of this product is restricted to research and development only. This product must be used by or directly under the supervision of a technically qualified individual as defined by TSCA. This product must not be used for commercial purposes or in formulations for commercial purposes.
SARA Section 313 (specific toxic chemical listings)
None of the ingredients are listed.
California Proposition 65
Prop 65 - Chemicals known to cause cancer
None of the ingredients are listed.
Prop 65 - Developmental toxicity
None of the ingredients are listed.
Prop 65 - Developmental toxicity, female
None of the ingredients are listed.
Prop 65 - Developmental toxicity, male
None of the ingredients are listed.
Information about limitation of use:
For use only by technically qualified individuals.
Other regulations, limitations and prohibitive regulations
Substance of Very High Concern (SVHC) according to the REACH Regulations (EC) No. 1907/2006.
None of the ingredients are listed.
The conditions of restrictions according to Article 67 and Annex XVII of the Regulation (EC) No 1907/2006 (REACH) for the manufacturing, placing on the market and use must be observed.
None of the ingredients is listed.
Annex XIV of the REACH Regulations (requiring Authorisation for use)
None of the ingredients is listed.
Chemical safety assessment:
A Chemical Safety Assessment has not been carried out.


16. OTHER INFORMATION

Safety Data Sheet according to Regulation (EC) No. 1907/2006 (REACH). The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. American Elements shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale. COPYRIGHT 1997-2016 AMERICAN ELEMENTS. LICENSED GRANTED TO MAKE UNLIMITED PAPER COPIES FOR INTERNAL USE ONLY.

About Hydroxyapatite Nanoparticles / Nanopowder

Hydroxyapatite Nanopowder or Nanoparticles, nanodots or nanocrystals are spherical or faceted high surface area oxide magnetic nanostructured particles. Nanoscale Hydroxyapatite Particles are typically 20-80 nanometers (nm) with specific surface area (SSA) in the 15 - 50 m2/g range and also available in with an average particle size of 100 nm range with a specific surface area of approximately 5 - 10 m2/g. Nano Hydroxyapatite Particles are also available in ultra high purity and high purity, transparent, and coated and dispersed forms. They are also available as a nanofluid through the AE Nanofluid production group. Nanofluids are generally defined as suspended nanoparticles in solution either using surfactant or surface charge technology. Nanofluid dispersion and coating selection technical guidance is also available. Other nanostructures include nanorods, nanowhiskers, nanohorns, nanopyramids and other nanocomposites. Surface functionalized nanoparticles allow for the particles to be preferentially adsorbed at the surface interface using chemically bound polymers.

Hydroxyapatite Nanoparticles / Nanopowder Synonyms

Hydroxylapatite; Calcium hydroxycalcium(1+) phosphate (4:1:3); Calcium hydroxyphosphate, Calcium phosphate tribasic; HAp; Hydroxylapatite; Tribasic calcium phosphate; Calcium hydroxide phosphate (5:1:3) ; Calcium orthophosphate, basic; Durapatite, 12167-74-7

Hydroxyapatite Nanoparticles / Nanopowder Chemical Identifiers

Linear Formula

[Ca5(OH)(PO4)3]x

Pubchem CID

29282806

MDL Number

MFCD00010904

EC No.

235-330-6

IUPAC Name

pentacalcium; hydroxide; triphosphate

SMILES

[OH-].[O-]P(=O)([O-])[O-].[O-]P(=O)([O-])[O-].[O-]P(=O)([O-])[O-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2]

InchI Identifier

InChI=1S/5Ca.3H3O4P.H2O/c;;;;;3*1-5(2,3)4;/h;;;;;3*(H3,1,2,3,4);1H2/q5*+2;;;;/p-10

InchI Key

XYJRXVWERLGGKC-UHFFFAOYSA-D

Packaging Specifications

Typical bulk packaging includes palletized plastic 5 gallon/25 kg. pails, fiber and steel drums to 1 ton super sacks in full container (FCL) or truck load (T/L) quantities. Research and sample quantities and hygroscopic, oxidizing or other air sensitive materials may be packaged under argon or vacuum. Shipping documentation includes a Certificate of Analysis and Safety Data Sheet (SDS). Solutions are packaged in polypropylene, plastic or glass jars up to palletized 440 gallon liquid totes, and 36,000 lb. tanker trucks.

Related Elements

See more Calcium products. Calcium (atomic symbol: Ca, atomic number: 20) is a Block S, Group 2, Period 4 element with an atomic weight of 40.078. The number of electrons in each of Calcium's shells is [2, 8, 8, 2] and its electron configuration is [Ar] 4s2. Calcium Bohr ModelThe calcium atom has a radius of 197 pm and a Van der Waals radius of 231 pm. Calcium was discovered and first isolated by Sir Humphrey Davy in 1808. It is the fifth most abundant element in the earth's crust and can be found in minerals such as dolomite, gypsum, plagioclases, amphiboles, pyroxenes and garnets. In its elemental form, calcium has a dull gray-silver appearance. Calcium is a reactive, soft metal that is a member of the alkaline earth elements. Elemental CalciumIt frequently serves as an alloying agent for other metals like aluminum and beryllium industrial materials like cement and mortar are composed of calcium compounds like calcium carbonate. It is also an biologically essential substance found in teeth, bones, and shells. The name "calcium" originates from the Latin word "calics," meaning lime.

Recent Research

Calcium oxalate crystals induces tight junction disruption in distal renal tubular epithelial cells by activating ROS/Akt/p38 MAPK signaling pathway., Yu, Lei, Gan Xiuguo, Liu Xukun, and An Ruihua , Ren Fail, 2017 Nov, Volume 39, Issue 1, p.440-451, (2017)

Inhibitory effect of an aqueous extract of Radix Paeoniae Alba on calcium oxalate nephrolithiasis in a rat model., Li, Xiaoran, Wang Wenyun, Su Yu, Yue Zhongjin, and Bao Junsheng , Ren Fail, 2017 Nov, Volume 39, Issue 1, p.120-129, (2017)

Calcium hydroxyapatite-based photocatalysts for environment remediation: Characteristics, performances and future perspectives., Piccirillo, C, and Castro P M. L. , J Environ Manage, 2017 May 15, Volume 193, p.79-91, (2017)

Effect of antiarrhythmic drugs on small conductance calcium - activated potassium channels., Simó-Vicens, Rafel, Sauter Daniel R. P., Grunnet Morten, Diness Jonas G., and Bentzen Bo H. , Eur J Pharmacol, 2017 May 15, Volume 803, p.118-123, (2017)

Encapsulation of cisplatin in a pegylated calcium phosphate nanoparticle (CPNP) for enhanced cytotoxicity to cancerous cells., Ding, Yang, Zhai Kang, Pei Pei, Lin Yue, Ma Yinchu, Zhu Huixia, Shao Mingfeng, Yang Xianzhu, and Tao Wei , J Colloid Interface Sci, 2017 May 01, Volume 493, p.181-189, (2017)

The Effects of Cerium Oxide Incorporation in Calcium Silicate Coating on Bone Mesenchymal Stem Cell and Macrophage Responses., Li, Kai, Yu Jiangming, Xie Youtao, You Mingyu, Huang Liping, and Zheng Xuebin , Biol Trace Elem Res, 2017 May, Volume 177, Issue 1, p.148-158, (2017)

Calcium Signaling During Meiotic Cell Cycle Regulation and Apoptosis in Mammalian Oocytes., Tiwari, Meenakshi, Prasad Shilpa, Shrivastav Tulsidas G., and Chaube Shail K. , J Cell Physiol, 2017 May, Volume 232, Issue 5, p.976-981, (2017)

Dietary calcium intake is inversely associated with blood pressure in Brazilian children., Magalhães, Elma Izze da Si, Pessoa Milene Cristine, Franceschini Sylvia do Carmo C., and Novaes Juliana Farias , Int J Food Sci Nutr, 2017 May, Volume 68, Issue 3, p.331-338, (2017)

Effect of double antibiotic and calcium hydroxide pastes on dislodgement resistance of an epoxy resin-based and two calcium silicate-based root canal sealers., Gokturk, Hakan, Bayram Emre, Bayram Huda Melike, Aslan Tugrul, and Ustun Yakup , Clin Oral Investig, 2017 May, Volume 21, Issue 4, p.1277-1282, (2017)

Alleviating effects of calcium on cobalt toxicity in two barley genotypes differing in cobalt tolerance., Lwalaba, Jonas Lwalaba Wa, Zvobgo Gerald, Fu Liangbo, Zhang Xuelei, Mwamba Theodore Mulembo, Muhammad Noor, Mundende Robert Prince Muk, and Zhang Guoping , Ecotoxicol Environ Saf, 2017 May, Volume 139, p.488-495, (2017)

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