Low-Dose Prostate Cancer Brachytherapy with Radioactive Palladium-Gold Nanoparticles.

Title Low-Dose Prostate Cancer Brachytherapy with Radioactive Palladium-Gold Nanoparticles.
Authors M. Laprise-Pelletier; J. Lagueux; M.F. Côté; T. LaGrange; M.A. Fortin
Journal Adv Healthc Mater
DOI 10.1002/adhm.201601120
Abstract

Prostate cancer (PCa) is one of the leading causes of death among men. Low-dose brachytherapy is an increasingly used treatment for PCa, which requires the implantation of tens of radioactive seeds. This treatment causes discomfort; these implants cannot be removed, and they generate image artifacts. In this study, the authors report on intratumoral injections of radioactive gold nanoparticles (Au NPs) as an alternative to seeds. The particles ((103) Pd:Pd@Au-PEG and (103) Pd:Pd@(198) Au:Au-PEG; 10-14 nm Pd@Au core, 36-48 nm hydrodynamic diameter) are synthesized by a one-pot process and characterized by electron microscopy. Administrated as low volume (2-4 µL) single doses (1.6-1.7 mCi), the particles are strongly retained in PCa xenograft tumors, impacting on their growth rate. After 4 weeks, a tumor volume inhibition of 56% and of 75%, compared to the controls, is observed for (103) Pd:Pd@Au-PEG NPs and (103) Pd:Pd@(198) Au:Au-PEG NPs, respectively. Skin necrosis is observed with (198) Au; therefore, Au NPs labeled with (103) Pd only are a more advisable choice. Overall, this is the first study confirming the impact of (103) Pd@Au NPs on tumor growth. This new brachytherapy procedure could allow tunable doses of radioactivity, administered with smaller needles than with the current technologies, and leading to fewer image artifacts.

Citation M. Laprise-Pelletier; J. Lagueux; M.F. Côté; T. LaGrange; M.A. Fortin.Low-Dose Prostate Cancer Brachytherapy with Radioactive Palladium-Gold Nanoparticles.. Adv Healthc Mater. 2017. doi:10.1002/adhm.201601120

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