Mitochondrial dynamics tracking with iridium(III) complexes.

Title	Mitochondrial dynamics tracking with iridium(III) complexes.
Authors	Y. Chen; T.W. Rees; L. Ji; H. Chao
Journal	Curr Opin Chem Biol
DOI	10.1016/j.cbpa.2017.11.006
Abstract	Since the discovery of mitochondrial dynamics, demand for dyes able to track this process has been a great. In contrast to static imaging, dynamic tracking requires superior photostability, low cytotoxicity and high resistance to the loss of mitochondrial membrane potential as well as appreciable tolerance to environmental changes. Recently, a variety of phosphorescent Ir(III) complexes have been found to localize in mitochondria and their applications as mitochondrial dynamics trackers have been assessed in cell monolayers, 3D MCSs and live animals. The examples presented here demonstrate that Ir(III) complexes constitute ideal candidates to meet the challenges of this topic.
Citation	Y. Chen; T.W. Rees; L. Ji; H. Chao.Mitochondrial dynamics tracking with iridium(III) complexes.. Curr Opin Chem Biol. 2018;43:5157. doi:10.1016/j.cbpa.2017.11.006

Related Elements

Iridium

77 Ir 192.217000000 Iridium

See more Iridium products. Iridium (atomic symbol: Ir, atomic number: 77) is a Block D, Group 9, Period 6 element with an atomic weight of 192.217. The number of electrons in each of iridium's shells is [2, 8, 18, 32, 15, 2] and its electron configuration is [Xe] 4f¹⁴ 5d⁷ 6s². Iridium Bohr Model The iridium atom has a radius of 136 pm and a Van der Waals radius of 202 pm. Iridium was discovered and first isolated by Smithson Tennant in 1803. In its elemental form, Iridium has a silvery white appearance. Iridium is a member of the platinum group of metals. Elemental Iridium It is the most corrosion resistant metal known and is the second-densest element (after osmium). It will not react with any acid and can only be attacked by certain molten salts, such as molten sodium chloride. Iridium is found as an uncombined element and in iridium-osmium alloys. Iridium's name is derived from the Greek goddess Iris, personification of the rainbow, on account of the striking and diverse colors of its salts.