Nickel pincer model of the active site of lactate racemase involves ligand participation in hydride transfer.

Title Nickel pincer model of the active site of lactate racemase involves ligand participation in hydride transfer.
Authors T. Xu; M.D. Wodrich; R. Scopelliti; C. Corminboeuf; X. Hu
Journal Proc Natl Acad Sci U S A
DOI 10.1073/pnas.1616038114
Abstract

Lactate racemase is the first enzyme known to possess a metal pincer active site. The enzyme interconverts d- and l-lactic acid, which is important for the assembly of cell walls in many microorganisms. Here, we report a synthetic model of the active site of lactate racemase, which features a pyridinium-based SCS pincer ligand framework bound to nickel. The model complex mediates the dehydrogenation of alcohols, a reaction relevant to lactate racemization. Experimental and computational data indicate ligand participation in the dehydrogenation reaction.

Citation T. Xu; M.D. Wodrich; R. Scopelliti; C. Corminboeuf; X. Hu.Nickel pincer model of the active site of lactate racemase involves ligand participation in hydride transfer.. Proc Natl Acad Sci USA. 2017;114(6):12421245. doi:10.1073/pnas.1616038114

Related Elements

Nickel

See more Nickel products. Nickel (atomic symbol: Ni, atomic number: 28) is a Block D, Group 4, Period 4 element with an atomic weight of 58.6934. Nickel Bohr ModelThe number of electrons in each of nickel's shells is [2, 8, 16, 2] and its electron configuration is [Ar]3d8 4s2. Nickel was first discovered by Alex Constedt in 1751. The nickel atom has a radius of 124 pm and a Van der Waals radius of 184 pm. In its elemental form, nickel has a lustrous metallic silver appearance. Nickel is a hard and ductile transition metal that is considered corrosion-resistant because of its slow rate of oxidation. Elemental NickelIt is one of four elements that are ferromagnetic and is used in the production of various type of magnets for commercial use. Nickel is sometimes found free in nature but is more commonly found in ores. The bulk of mined nickel comes from laterite and magmatic sulfide ores. The name originates from the German word kupfernickel, which means "false copper" from the illusory copper color of the ore.

Related Forms & Applications