Optimal injected dose ratio of a very rapid 1-day protocol of myocardial perfusion imaging with cadmium-zinc-telluride single-photon emission tomography: simulation and phantom study.

Title Optimal injected dose ratio of a very rapid 1-day protocol of myocardial perfusion imaging with cadmium-zinc-telluride single-photon emission tomography: simulation and phantom study.
Authors M. Shinjyo; M. Naniwa; N. Kubo; Y. Nishimura; K. Kiso; K. Fukuchi
Journal Nucl Med Commun
DOI 10.1097/MNM.0000000000000689
Abstract

OBJECTIVE: Cadmium-zinc-telluride detectors enable shorter acquisition durations in myocardial perfusion imaging (MPI), but the time interval of sequential scanning is still unchanged in clinical practice. We designed a very rapid 1-day protocol of MPI using cadmium-zinc-telluride single-photon emission tomography and evaluated the optimal dose ratio between two scanning acquisitions by means of simulations and phantom experiments.

METHODS: We intended to perform a 1-day MPI within 140?min and simulate radioactivities in the second scan under various injected dose ratios. To apply this, a cardiac phantom was scanned with various radioactivities and scans were compared with a reference scan with the ideal tracer concentrations.

RESULTS: In the stress-first protocol, the dose ratio 1?:?5 was enough to show the same regional percentage uptake compared with the reference. However, in the rest-first protocol, the regional percentage uptakes were higher than those of the reference image even with a 1?:?6 dose ratio.

CONCLUSION: The injected dose ratio 1?:?5 is optimal in a stress-first rapid 1-day protocol. The rest-first protocol is not appropriate because a dose ratio greater than 1?:?6 is required to withdraw shine-through artifacts.

Citation M. Shinjyo; M. Naniwa; N. Kubo; Y. Nishimura; K. Kiso; K. Fukuchi.Optimal injected dose ratio of a very rapid 1-day protocol of myocardial perfusion imaging with cadmium-zinc-telluride single-photon emission tomography: simulation and phantom study.. Nucl Med Commun. 2017. doi:10.1097/MNM.0000000000000689

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