PEGylated chitosan nanoparticles with embedded bismuth sulfide for dual-wavelength fluorescent imaging and photothermal therapy.

Title PEGylated chitosan nanoparticles with embedded bismuth sulfide for dual-wavelength fluorescent imaging and photothermal therapy.
Authors K. Wang; J. Zhuang; Y. Liu; M. Xu; J. Zhuang; Z. Chen; Y. Wei; Y. Zhang
Journal Carbohydr Polym
DOI 10.1016/j.carbpol.2018.01.005
Abstract

It is of great significance to construct multifunctional nanosystems for simultaneous imaging and therapy of cancer cells. Herein, PEGylated chitosan nanoparticles with embedded bismuth sulfide were facilely fabricated via reverse-microemulsion method for fluorescent imaging and photothermal therapy of HepG2 cells. The obtained BSA-BiS-CG-PEG nanospheres revealed dual-wavelength fluorescence, which were spectrally isolated from the bioautofluorescence. Moreover, they demonstrated remarkable photothermal conversion efficiency and stability. Importantly, these small BSA-BiS-CG-PEG nanoparticles shown a zeta potential of?+?42.3?mV, which could rapidly get into HepG2 cells and locate in the cytoplasm and nuclei of cells. Based on their excellent photothermal effect and high cellular uptake, BSA-BiS-CG-PEG nanoparticles could efficiently kill HepG2 cells under an 808?nm laser irradiation. This construction strategy can be used for preparation of fluorescent chitosan nanoparticles with other therapeutic agents embedded, which would provide a versatile platform for dual-wavelength fluorescent imaging guided therapy of cancer.

Citation K. Wang; J. Zhuang; Y. Liu; M. Xu; J. Zhuang; Z. Chen; Y. Wei; Y. Zhang.PEGylated chitosan nanoparticles with embedded bismuth sulfide for dual-wavelength fluorescent imaging and photothermal therapy.. Carbohydr Polym. 2018;184:445452. doi:10.1016/j.carbpol.2018.01.005

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Bismuth

See more Bismuth products. Bismuth (atomic symbol: Bi, atomic number: 83) is a Block P, Group 15, Period 6 element with an atomic radius of 208.98040. The number of electrons in each of Bismuth's shells is 2, 8, 18, 32, 18, 5 and its electron configuration is [Xe] 4f14 5d10 6s2 6p3. Bismuth Bohr ModelThe bismuth atom has a radius of 156 pm and a Van der Waals radius of 207 pm. In its elemental form, bismuth is a silvery white brittle metal. Bismuth is the most diamagnetic of all metals and, with the exception of mercury, its thermal conductivity is lower than any other metal. Elemental BismuthBismuth has a high electrical resistance, and has the highest Hall Effect of any metal (i.e., greatest increase in electrical resistance when placed in a magnetic field). Bismuth is found in bismuthinite and bismite. It is also produced as a byproduct of lead, copper, tin, molybdenum and tungsten extraction. Bismuth was first discovered by Early Man. The name Bismuth originates from the German word 'wissmuth,' meaning white mass.

Sulfur

See more Sulfur products. Sulfur (or Sulphur) (atomic symbol: S, atomic number: 16) is a Block P, Group 16, Period 3 element with an atomic radius of 32.066. Sulfur Bohr ModelThe number of electrons in each of Sulfur's shells is 2, 8, 6 and its electron configuration is [Ne] 3s2 3p4. In its elemental form, sulfur has a light yellow appearance. The sulfur atom has a covalent radius of 105 pm and a Van der Waals radius of 180 pm. In nature, sulfur can be found in hot springs, meteorites, volcanoes, and as galena, gypsum, and epsom salts. Sulfur has been known since ancient times but was not accepted as an element until 1777, when Antoine Lavoisier helped to convince the scientific community that it was an element and not a compound.

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