American Elements pharmaceutical production facility in Bluffdale, Utah operates under fully documented GMP standards. It has been fully audited by Bristol Myers Squibb, Pfizer and many other important pharma customers.

Several key pharmaceutical, nutritional and cosmetic additives have been developed by or in cooperation with American Elements. For example, we co-developed a new class of excipient powder now in common use in such drugs as Abilify™.

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Innovation Case Study #21: American Elements Invents New Rapid Dissolve Pharmaceutical Powder for Psychiatric Patients

#21: American Elements Invents New Rapid Dissolve Pharmaceutical Powder for Psychiatric Patients

The Challenge

Formulating new innovations in drugs often requires the development of two separate materials-the performing “Active Ingredient” and the “Excipient” which determines in which region(s) and how quickly the active ingredient will be absorbed in the patient’s body. Bristol Myers Squibb sought a new ultra quick dissolving powder that could easily pack into a pill using existing equipment for its new schizophrenia drug, Abilify™.

The Innovation

To meet this gap in excipient technology, American Elements invented a new class of micronized crystalline powder that both dissolved in the mouth instantly and exhibited excellent packing density. Once approved by BMS, we scaled the process to full scale production at our Murray, Utah facility.

The Result

Bristol Myers Squibb received FDA approval in 2002 for use of Abilify to treat schizophrenia. The drug is now in wide use. The excipient developed by American Elements can now be found in numerous other drugs as well. In 2012, American Elements transferred this technology to the Engineered Materials division of the JM Huber Corporation which markets the powder under the trade name RxCIPIENTS® FM1000.

Selected Products Supplied to the Pharmaceuticals & Cosmetics Industry

Aluminum Acetotartrate Aluminum Acrylate Ammonium Dihydrogen Arsenate Ammonium Hexafluorogermanate
Ammonium Iron(II) Sulfate Hexahydrate Ammonium Manganese(III) Pyrophosphate Boron Citrate Bromo(triphenylphosphine)gold(I)
Calcium Carbonate Calcium Lactobionate Monohydrate Calcium Perchlorate Hydrate Calcium Phosphate Dibasic Anhydrous
Calcium Phosphate Dibasic Dihydrate Calcium-44 Carbonate Isotope Carbonyl Iron Powder Carboplatin
Cesium Carbonate Chromium Phosphate Tetrahydrate cis-Diamminedichloroplatinum Copper Aluminum Zinc Alloy
Cyclopentadienylrhenium Tricarbonyl Disodium Calcium Ethylenediaminetetraacetate Ferric Hydroxide Oxide Fumed Silica
Gold Colloid Iron Blocks Iron Cubes Iron Foil
Iron(III) Chloride Iron(III) Oxide Powder Lithium Carbonate Lithium Iodide
Lithium Iodide Trihydrate Magnesium Aluminum Silicate Magnesium Chromate Hydrate Magnesium Granules
Mangafodipir Trisodium Manganese Oxide (Mn2O3) Manganese(II,III) Oxide Miboplatin
Molybdenum Oxide Pellets Multi-Walled Carbon Nanotubes Nedaplatin Neodymium Fluoride
Nickel Tin Oxide Dihydrate Oxaliplatin Platinum Oxide Powder Potassium Bromide
Potassium Bromide Windows Potassium Isopropoxide Reduced Graphene Oxide Samarium Oxide Powder
Satraplatin Silicon Nanowires Sodium 2-mercaptoethanesulfonate Sodium Benzoate
Sodium Dodecylbenzenesulfonate Sodium Nitrate Sodium Salicylate Sodium Selenate Decahydrate
Sodium Selenide Sodium Stannate Sodium Stannate Trihydrate Spirogermanium
Titanium Oxide Nanoparticle Dispersion Titanium Oxide Nanoparticles / Nanopowder Titanium(IV) Oxide, Brookite Nanopowder trans-Diamminedichloroplatinum(II)
Ytterbium Chloride Ytterbium Fluoride Zinc Acetate Zinc Carbonate
Zinc Carbonate Basic Zinc Nanoparticle Dispersion Zinc Nanoparticles Zinc Oleate
Zinc Phosphate Dihydrate