American Elements pharmaceutical production facility in Bluffdale, Utah operates under fully documented GMP standards. It has been fully audited by Bristol Myers Squibb, Pfizer and many other important pharma customers.

Several key pharmaceutical, nutritional and cosmetic additives have been developed by or in cooperation with American Elements. For example, we co-developed a new class of excipient powder now in common use in such drugs as Abilify™.

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Innovation Case Study #21: American Elements Invents New Rapid Dissolve Pharmaceutical Powder for Psychiatric Patients

#21: American Elements Invents New Rapid Dissolve Pharmaceutical Powder for Psychiatric Patients

The Challenge

Formulating new innovations in drugs often requires the development of two separate materials-the performing “Active Ingredient” and the “Excipient” which determines in which region(s) and how quickly the active ingredient will be absorbed in the patient’s body. Bristol Myers Squibb sought a new ultra quick dissolving powder that could easily pack into a pill using existing equipment for its new schizophrenia drug, Abilify™.

The Innovation

To meet this gap in excipient technology, American Elements invented a new class of micronized crystalline powder that both dissolved in the mouth instantly and exhibited excellent packing density. Once approved by BMS, we scaled the process to full scale production at our Murray, Utah facility.

The Result

Bristol Myers Squibb received FDA approval in 2002 for use of Abilify to treat schizophrenia. The drug is now in wide use. The excipient developed by American Elements can now be found in numerous other drugs as well. In 2012, American Elements transferred this technology to the Engineered Materials division of the JM Huber Corporation which markets the powder under the trade name RxCIPIENTS® FM1000.

Selected Products Supplied to the Pharmaceuticals & Cosmetics Industry

Aluminum Acetotartrate Aluminum Acrylate Ammonium Dihydrogen Arsenate Ammonium Hexafluorogermanate
Ammonium Iron(II) Sulfate Hexahydrate Ammonium Manganese(III) Pyrophosphate Boron Citrate Bromo(triphenylphosphine)gold(I)
Calcium Carbonate Calcium Lactobionate Monohydrate Calcium Phosphate Dibasic Anhydrous Calcium Phosphate Dibasic Dihydrate
Calcium-44 Carbonate Isotope Carboplatin Cesium Carbonate Chromium Phosphate Tetrahydrate
cis-Diamminedichloroplatinum Copper Aluminum Zinc Alloy Cyclopentadienylrhenium Tricarbonyl Disodium Calcium Ethylenediaminetetraacetate
Ferric Hydroxide Oxide Fumed Silica Gold Colloid Iron Foil
Iron(III) Chloride Iron(III) Oxide Powder Lithium Carbonate Lithium Iodide
Lithium Iodide Trihydrate Magnesium Chromate Hydrate Magnesium Granules Mangafodipir Trisodium
Manganese Oxide (Mn2O3) Manganese(II,III) Oxide Miboplatin Molybdenum Oxide Pellets
Multi-Walled Carbon Nanotubes Nedaplatin Neodymium Fluoride Oxaliplatin
Platinum Oxide Powder Potassium Bromide Potassium Bromide Windows Reduced Graphene Oxide
Samarium Oxide Powder Satraplatin Silicon Nanowires Sodium 2-mercaptoethanesulfonate
Sodium Benzoate Sodium Dodecylbenzenesulfonate Sodium Nitrate Sodium Salicylate
Sodium Selenate Sodium Selenide Sodium Stannate Sodium Stannate Trihydrate
Spirogermanium Titanium Oxide Nanoparticle Dispersion Titanium Oxide Nanoparticles / Nanopowder trans-Diamminedichloroplatinum(II)
Ytterbium Chloride Ytterbium Fluoride Zinc Acetate Zinc Carbonate
Zinc Carbonate Basic Zinc Nanoparticle Dispersion Zinc Nanoparticles Zinc Oleate
Zinc Phosphate Dihydrate