Protein-Stabilized Gadolinium Oxide-Gold Nanoclusters Hybrid for Multimodal Imaging and Drug Delivery.

Title Protein-Stabilized Gadolinium Oxide-Gold Nanoclusters Hybrid for Multimodal Imaging and Drug Delivery.
Authors L. Han; J.M. Xia; X. Hai; Y. Shu; X.W. Chen; J.H. Wang
Journal ACS Appl Mater Interfaces
DOI 10.1021/acsami.7b00246
Abstract

A protein-stabilized multifunctional theranostic nanoplatform, gadolinium oxide-gold nanoclusters hybrid (Gd2O3-AuNCs), is constructed for multimodal imaging and drug delivery. The Gd2O3-AuNCs nanohybrid is developed by integrating Gd2O3 nanocrystals and gold nanoclusters into bovine serum albumin scaffold as a stabilizer. The nanohybrid exhibits favorable biocompatibility and is capable of enhancing the contrast in magnetic resonance (MR) and X-ray computed tomography (CT) imaging. Meanwhile, the integrated AuNCs component not only endows the nanohybrid to produce red fluorescence, but also sensitizes the generation of singlet oxygen upon near-infrared laser stimulation at 808 nm. Bovine serum albumin surrounding the nanoparticles makes Gd2O3-AuNCs a brilliant carrier for the delivery of indocyanine green (ICG). ICG loading endows the Gd2O3-AuNCs-ICG nanocomposite with a near-infrared fluorescence imaging capability, and improves its photodynamic property and photothermal capability. Ultimately, further experiments have demonstrated that Gd2O3-AuNCs-ICG nanocomposite is a promising theranostic agent for image guided cancer therapy.

Citation L. Han; J.M. Xia; X. Hai; Y. Shu; X.W. Chen; J.H. Wang.Protein-Stabilized Gadolinium Oxide-Gold Nanoclusters Hybrid for Multimodal Imaging and Drug Delivery.. ACS Appl Mater Interfaces. 2017. doi:10.1021/acsami.7b00246

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Gadolinium

See more Gadolinium products. Gadolinium (atomic symbol: Gd, atomic number: 64) is a Block F, Group 3, Period 6 element with an atomic radius of 157.25. Gadolinium Bohr ModelThe number of electrons in each of Gadolinium's shells is [2, 8, 18, 25, 9, 2] and its electron configuration is [Xe] 4f7 5d1 6s2. The gadolinium atom has a radius of 180 pm and a Van der Waals radius of 237 pm. Gadolinium was discovered by Jean Charles Galissard de Marignac in 1880 and first isolated by Lecoq de Boisbaudran in 1886. In its elemental form, gadolinium has a silvery-white appearance. Gadolinium is a rare earth or lanthanide element that possesses unique properties advantageous to specialized applications such as semiconductor fabrication and nuclear reactor shielding. Elemental Gadolinium PictureIt is utilized for both its high magnetic moment (7.94μ B) and in phosphors and scintillator crystals. When complexed with EDTA ligands, it is used as an injectable contrast agent for MRIs. The element is named after the Finnish chemist and geologist Johan Gadolin.

Gold

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