Radioprotective and radiomitigative effects of BP-C2, a novel lignin-derived polyphenolic composition with ammonium molybdate, in two mouse strains exposed to total body irradiation.

Title Radioprotective and radiomitigative effects of BP-C2, a novel lignin-derived polyphenolic composition with ammonium molybdate, in two mouse strains exposed to total body irradiation.
Authors V.N. Bykov; I.S. Drachev; S.Yu Kraev; M.A. Maydin; E.A. Gubareva; S.E. Pigarev; V.N. Anisimov; I.A. Baldueva; E.I. Fedoros; A.V. Panchenko
Journal Int J Radiat Biol
DOI 10.1080/09553002.2018.1416204
Abstract

PURPOSE: There remains an unmet medical need for radioprotective and mitigative agents. BP-C2 is a novel lignin-derived polyphenolic composition with ammonium molybdate, developed as radioprotector/radiomitigator.

OBJECTIVES: The present study evaluated BP-C2 for the mitigation of acute radiation syndrome (ARS).

METHODS: A total-body irradiation mouse model (TBI, 4.0-8.0?Gy) was used in the study.

RESULTS: In a 30-day survival study, performed in CBA mice, BP-C2, at a dosage of 81.0?mg/kg, improved survival (dose reduction factor (DRF)?=?1.1) and increased the formation of endogenous spleen colony-forming units (CFU). In C57BL/6 mice, BP-C2, when administered daily for 7 days, starting 24?hours after TBI, also improved survival. In animals irradiated with 5.0?Gy, BP-C2 increased the number of CFUs (6.7?±?5.1) compared to the 5.0?Gy placebo group (2.3?±?2.3, p?=?.0245). The number of surviving intestinal crypts was maintained in the 5.0?Gy BP-C2 group (133.7?±?13.9), in contrast to the 5.0?Gy placebo group (124.2?±?10.5, p?

CONCLUSION: BP-C2 mitigates radiation-induced damage in mid-lethal range of radiation doses. Effects are mediated by enhancement of extramedullar hematopoiesis in the spleen and a protective effect on the intestinal epithelium.

Citation V.N. Bykov; I.S. Drachev; S.Yu Kraev; M.A. Maydin; E.A. Gubareva; S.E. Pigarev; V.N. Anisimov; I.A. Baldueva; E.I. Fedoros; A.V. Panchenko.Radioprotective and radiomitigative effects of BP-C2, a novel lignin-derived polyphenolic composition with ammonium molybdate, in two mouse strains exposed to total body irradiation.. Int J Radiat Biol. 2018;94(2):114123. doi:10.1080/09553002.2018.1416204

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