A bioluminescent strategy for imaging palladium in living cells and animals with chemoselective probes based on luciferin-luciferase system.

Author(s) Ke, B.; Chen, H.; Cui, Y.; Ma, L.; Liu, Y.; Hu, X.; Bai, Y.; Du, L.; Li, M.
Journal Talanta
Date Published 2019 Mar 01
Abstract

To develop a strategy for visualizing palladium species in the biological system, several turn-on bioluminescent probes were designed and synthesized by using a Pd-induced reductive reaction herein. Such probes exhibited high sensitivity (detection limit: 0.5 μM) and excellent selectivity toward Pdin vitro. In particular, probe 2 was identified as a viable molecule with the capability of visualizing the fluctuations of level and distribution of Pd in living cells and animals, which provides a valuable tool for tracing Pd in biological system.

DOI 10.1016/j.talanta.2018.11.006
Keywords Animals; Cell Line; Cell Survival; Limit of Detection; Luciferases; Luminescent Agents; Luminescent Measurements; Mice; Optical Imaging; Palladium
ISSN 1873-3573
Citation Ke B, Chen H, Cui Y, Ma L, Liu Y, Hu X, et al. A bioluminescent strategy for imaging palladium in living cells and animals with chemoselective probes based on luciferin-luciferase system. Talanta. 2019;194:925-929.