A solid support generator of the Auger electron emitter rhodium-103m from [Pd]palladium.

Author(s) Jensen, A.I.; Zhuravlev, F.; Severin, G.; Magnus, C.Busk; Fonslet, J.; Köster, U.; Jensen, M.
Journal Appl Radiat Isot
Date Published 2020 Feb
Abstract

Auger electron therapy is an attractive modality for targeting microscopic tumors. Rhodium-103 m (Rh, T = 56.1 min) is a promising Auger electron emitter that can be obtained as the decay product of palladium-103 (Pd, T = 16.99 days). Pd was chelated in a lipophilic derivative of the 16aneS4 macrocycle and the complex was trapped on a C18 cartridge. Elution with dilute hydrochloric acid gave radiochemically pure Rh. We hypothesize this to be through a combination of the Szilard-Chalmers effect and transient ionization.

DOI 10.1016/j.apradiso.2019.108985
ISSN 1872-9800
Citation Jensen AI, Zhuravlev F, Severin G, Magnus CB, Fonslet J, Köster U, et al. A solid support generator of the Auger electron emitter rhodium-103m from [Pd]palladium. Appl Radiat Isot. 2020;156:108985.

Related Applications, Forms & Industries