Aluminum Chloride Causes the Dysfunction of Testes Through Inhibiting the ATPase Enzyme Activities and Gonadotropin Receptor Expression in Rats.

Author(s) Sun, X.; Sun, H.; Yu, K.; Wang, Z.; Liu, Y.; Liu, K.; Zhu, Y.; Li, Y.
Journal Biol Trace Elem Res
Date Published 2018 Jun
Abstract

The aim of this experiment is to explore the effects of aluminum chloride (AlCl) on the ATPase enzymes and gonadotropin receptors in the testes. Eighty male Wistar rats were orally exposed to 0 mg/kg body weight (BW) (control group, CG), 64 mg/kg BW (low-dose group, LG), 128 mg/kg BW (mid-dose group, MG), or 256 mg/kg BW (high-dose group, HG) for 120 days. The microstructure and ultrastructure of testes; the activities of Na-K-ATPase, Mg-ATPase, and Ca-ATPase; and the mRNA and protein expressions of follicle-stimulating hormone receptor (FSHR) and luteinizing hormone receptors (LHR) in the testes were examined. The results showed that the testes histological structure were damaged; the activities of Na-K-ATPase, Mg-ATPase, and Ca-ATPase, the mRNA and protein expressions of FSHR and LHR in the testes were all decreased in the rats with AlCl exposure. It indicates that AlCl causes the dysfunction of testes in rats.

DOI 10.1007/s12011-017-1120-1
ISSN 1559-0720
Citation Sun X, Sun H, Yu K, Wang Z, Liu Y, Liu K, et al. Aluminum Chloride Causes the Dysfunction of Testes Through Inhibiting the ATPase Enzyme Activities and Gonadotropin Receptor Expression in Rats. Biol Trace Elem Res. 2018;183(2):296-304.

Related Applications, Forms & Industries