Amide-Directed C-H Sodiation by a Sodium Hydride/Iodide Composite.

Author(s) Huang, Y.; Chan, G.Hao; Chiba, S.
Journal Angew Chem Int Ed Engl
Date Published 2017 Jun 01
Abstract

A new protocol for amide-directed ortho and lateral C-H sodiation is enabled by sodium hydride (NaH) in the presence of either sodium iodide (NaI) or lithium iodide (LiI). The transient organosodium intermediates could be transformed into functionalized aromatic compounds.

DOI 10.1002/anie.201702512
ISSN 1521-3773
Citation Huang Y, Chan GH, Chiba S. Amide-Directed C-H Sodiation by a Sodium Hydride/Iodide Composite. Angew Chem Int Ed Engl. 2017;56(23):6544-6547.

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