Amorphous metal boride as a novel platform for acetylcholinesterase biosensor development and detection of organophosphate pesticides.

Author(s) Lu, X.; Li, Y.; Tao, L.; Song, D.; Wang, Y.; Li, Y.; Gao, F.
Journal Nanotechnology
Date Published 2019 Feb 01
Abstract

The exploration of new materials for modifying electrodes is important to advance electrochemical biosensors. Herein, we demonstrated that amorphous bimetallic boride material (Co-2Ni-B) prepared by a simple and facile aqueous reaction is an efficient matrix to immobilize acetylcholinesterase (AChE) to construct a biosensor for the determination of organophosphate pesticides. The effects of different composition and crystallinity on its electrochemical performance are investigated, and the optimization studies of the biological transducer were also discussed. Under optimal conditions, the fabricated sensor showed good analytical performance for the determination of chlorpyrifos with a low limit of detection (2.83 pM) and a wide linear range (3 pM-300 nM). The proposed biosensor also demonstrated high reproducibility, stability and accuracy. The impressive performance was due to the excellent conductivity and the unique amorphous bimetal-metalloid complex nanostructure. These results introduce a new class of promising materials as a robust platform for biosensor applications.

DOI 10.1088/1361-6528/aaee3f
Keywords Acetylcholinesterase; Biosensing Techniques; Boron Compounds; Electrodes; Metals; Organophosphates; Pesticides; Reproducibility of Results
ISSN 1361-6528
Citation Lu X, Li Y, Tao L, Song D, Wang Y, Li Y, et al. Amorphous metal boride as a novel platform for acetylcholinesterase biosensor development and detection of organophosphate pesticides. Nanotechnology. 2019;30(5):055501.

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