Antimicrobial potential of bismuth lipophilic nanoparticles embedded into chitosan-based membrane.

Author(s) Martínez-Martínez, M.Antonio; Hernandez-Delgadillo, R.; Abada, B.Saad; Pineda-Aguilar, N.; Solís-Soto, J.Manuel; Nakagoshi-Cepeda, M.Argelia Ak; Nakagoshi-Cepeda, S.Eduardo; Chellam, S.; Sánchez-Nájera, R.Isela; Cabral-Romero, C.
Journal Dent Mater J
Date Published 2019 May 17
Abstract

The objective of this work was to analyze the antimicrobial and antibiofilm activities of bismuth lipophilic nanoparticles (BisBAL NPs) incorporated into chitosan-based membranes. Chitosan-based membranes were homogeneously embedded with BisBAL NPs, confirming the bismuth presence by scanning electron microscopy. The tensile strength of chitosan-based membrane alone or with BisBAL NPs showed similar results as elongation, suggesting that BisBAL NP addition did not affect membrane mechanical properties. Chitosan-based membranes complemented with 100 µM of BisBAL NPs caused a complete inhibition of biofilm formation and a 90-98% growth inhibition of six different oral pathogens. Cytotoxicity studies revealed that 80% of human gingival fibroblasts were viable after a 24-h exposure to the chitosan-based membrane with 100 µM of BisBAL NPs and collagen. Altogether, we conclude that the biological properties of chitosan-based membranes supplemented with BisBAL NPs could be a very interesting option for tissue regeneration.

DOI 10.4012/dmj.2018-173
ISSN 1881-1361
Citation Martínez-Martínez MA, Hernandez-Delgadillo R, Abada BS, Pineda-Aguilar N, Solís-Soto JM, Nakagoshi-Cepeda MA, et al. Antimicrobial potential of bismuth lipophilic nanoparticles embedded into chitosan-based membrane. Dent Mater J. 2019.