Author(s) Chen, C.; Yao, C.; Yang, J.; Luo, D.; Kong, X.; Chung, S.M.; Lee, I.S.
Journal Colloids Surf B Biointerfaces
Date Published 2017 Mar 01
Abstract

In this study, sirolimus (SRL) was loaded within biomimetic apatite formed on cobalt-chromium (Co-Cr) alloy, which has been reported for the first time, to inhibit the in-stent restenosis. Two different groups of loading SRL within biomimetic apatite were prepared: Group A (mono-layer of apatite/SRL) and Group B (bi-layer of apatite/SRL). Group A and Group B showed the biphasic pattern of SRL release up to 40 and 90days, respectively. The attachment of human artery smooth muscle cell (HASMC) for both Group A and Group B was significantly inhibited, and proliferation dramatically decreased with the release of SRL. Noteworthily, biomimetic apatite alone also suppressed the SMC proliferation. The porous biomimetic apatite uniformly covered Co-Cr stent without crack or webbings. After balloon expansion, the integrity of biomimetic apatite was sufficient to resist delamination or destruction. Thus, this study demonstrated that biomimetic apatite is a promising drug carrier for potential use in stents.

DOI 10.1016/j.colsurfb.2016.12.021
ISSN 1873-4367
Citation Colloids Surf B Biointerfaces. 2017;151:156164.

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