Case of early-stage gastric cancer identified in the gastric mucosa with lanthanum phosphate deposition.

Author(s) Takatsuna, M.; Takeuchi, M.; Usuda, H.; Terai, S.
Journal Endosc Int Open
Date Published 2019 Jul
Abstract

 A 78-year-old man with infection had been undergoing hemodialysis for chronic renal failure and receiving lanthanum carbonate preparations for 3 years. Endoscopy revealed fine white granular discoloration throughout the stomach, a moderately reddish depression on the lesser curvature of the gastric angle, and white granular discoloration in the surrounding area. A magnified image using narrow-band imaging showed that the depressed part had irregular vascular and pit structures. We established a diagnosis of intramucosal gastric cancer and performed endoscopic submucosal dissection. Histopathological examination revealed a well-differentiated adenocarcinoma that was confined to the mucosa of the depressed area. Moreover, using an electron probe microanalyzer-equipped electron microscope, we found that the degree of lanthanum deposition was lower in the tumor region than in the non-tumor region. Thus, the current case can help in understanding the relationship between lanthanum deposition and early-stage gastric cancer. Because gastric cancers can occur in lanthanum deposit-containing mucosa, esophagogastroduodenoscopy should be used carefully after understanding the characteristics of early- stage gastric cancer in such cases.

DOI 10.1055/a-0918-5804
ISSN 2364-3722
Citation Takatsuna M, Takeuchi M, Usuda H, Terai S. Case of early-stage gastric cancer identified in the gastric mucosa with lanthanum phosphate deposition. Endosc Int Open. 2019;7(7):E893-E895.

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