Catalytic Functionalization of a Single C-F Bond of Trifluoromethylarenes Assisted by an ortho-Silyl Group Using a Trityl-Based All-in-One Reagent with Ytterbium Triflate Catalyst.

Author(s) Kim, Y.; Kanemoto, K.; Shimomori, K.; Hosoya, T.; Yoshida, S.
Journal Chemistry
Date Published 2020 Mar 17

Catalytic thiolation and azidation of a single C-F bond of trifluoromethylarenes were achieved assisted by an ortho-silyl group with all-in-one reagents to generate trityl cation and nucleophiles. The reactions catalyzed by ytterbium triflate efficiently afforded a wide variety of difluoromethylenes avoiding the further C-F bond cleavage, by virtue of the mild conditions without the generation of a Brønsted acid.

DOI 10.1002/chem.202001315
ISSN 1521-3765
Citation Chemistry. 2020.

Related Applications, Forms & Industries