Catalyzing the Hydrodefluorination of CF3-substituted Alkenes by PhSiH3. H• Transfer from a Nickel Hydride.

Author(s) Yao, C.; Wang, S.; Norton, J.R.; Hammond, M.
Journal J Am Chem Soc
Date Published 2020 Jan 14
Abstract

The hydrodefluorination of CF3-substituted alkenes can be catalyzed by a nickel(II) hydride bearing a pincer ligand. The cata-lyst loading can be as low as 1 mol%. gem-Difluoroalkenes containing a number of functional groups can be formed in good to excellent yields, by a radical mechanism initiated by H• transfer from the nickel hydride. The relative reactivity of various substrates supports the proposed mechanism, as does a TEMPO trapping experiment.

DOI 10.1021/jacs.9b13757
ISSN 1520-5126
Citation Yao C, Wang S, Norton JR, Hammond M. Catalyzing the Hydrodefluorination of CF3-substituted Alkenes by PhSiH3. H• Transfer from a Nickel Hydride. J Am Chem Soc. 2020.

Related Applications, Forms & Industries