Chiral Magnesium Bisphosphate-Catalyzed Asymmetric Double C(sp)-H Bond Functionalization Based on Sequential Hydride Shift/Cyclization Process.

Author(s) Mori, K.; Isogai, R.; Kamei, Y.; Yamanaka, M.; Akiyama, T.
Journal J Am Chem Soc
Date Published 2018 May 11
Abstract

Described herein is a chiral magnesium bisphosphate-catalyzed asymmetric double C(sp)-H bond functionalization triggered by a sequential hydride shift/cyclization process. This reaction consists of stereoselective domino C(sp)-H bond functionalization: (1) a highly enantio- and diastereoselective C(sp)-H bond functionalization by chiral magnesium bisphosphate (first [1,5]-hydride shift), and (2) a highly diastereoselective C(sp)-H bond functionalization by an achiral catalyst (Yb(OTf), second [1,5]-hydride shift).

DOI 10.1021/jacs.8b02761
ISSN 1520-5126
Citation Mori K, Isogai R, Kamei Y, Yamanaka M, Akiyama T. Chiral Magnesium Bisphosphate-Catalyzed Asymmetric Double C(sp)-H Bond Functionalization Based on Sequential Hydride Shift/Cyclization Process. J Am Chem Soc. 2018.

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