Comparing a thioglycosylated chlorin and phthalocyanine as potential theranostic agents.

Author(s) Singh, S.; Aggarwal, A.; Bhupathiraju, N.V.S.Dinesh; Jovanovic, I.Radivojevi; Landress, M.; Tuz, M.Paola; Gao, R.; Drain, C.M.
Journal Bioorg Med Chem
Date Published 2020 Feb 01
Abstract

Herein we describe the design, efficient synthesis, and photophysical properties of two macrocycle dyes for cancer theranostics. This study compares a glycosylated chlorin with a glycosylated phthalocyanine designed to specifically target cancer, wherein the photophysical properties enable both fluorescence imaging and the sensitization of the formation of reactive oxygen species (ROS) for photodynamic therapy. Both the compounds show low darktoxicity (IC > 100 μM). The glycosylated phthalocyanine showed low phototoxicity (IC > 100 μM) while glycosylated chlorin showed high phototoxicity (IC = 1-2 μM). ZnPcGlc has low solubility and also form aggregates in aqueous media, thus resulting in minimal uptake in two different human breast cancer cell lines: MDA-MB-231 and MCF-7. The glycosylated chlorin however was efficiently taken up by these two cell lines, thus allows fluorescence imaging in cells and in xenograft tumor model in mice. In this study, we find that the chlorin conjugate is the more promising theranostic agent.

DOI 10.1016/j.bmc.2019.115259
ISSN 1464-3391
Citation Singh S, Aggarwal A, Bhupathiraju NV, Jovanovic IR, Landress M, Tuz MP, et al. Comparing a thioglycosylated chlorin and phthalocyanine as potential theranostic agents. Bioorg Med Chem. 2020;28(3):115259.

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