Copper-catalyzed coupling of anthranils and α-keto acids: direct synthesis of α-ketoamides.

Author(s) Li, P.G.; Zhu, H.; Fan, M.; Yan, C.; Shi, K.; Chi, X.W.; Zou, L.H.
Journal Org Biomol Chem
Date Published 2019 May 29
Abstract

Copper-catalyzed coupling of α-keto acids with anthranils is reported for the synthesis of α-ketoamides. This process involves N-O/C-O bond cleavages and C-N bond formation. Furthermore, the decarboxylation of α-keto acids can be successfully suppressed under redox-neutral conditions.

DOI 10.1039/c9ob00822e
ISSN 1477-0539
Citation Li P-, Zhu H, Fan M, Yan C, Shi K, Chi X-, et al. Copper-catalyzed coupling of anthranils and α-keto acids: direct synthesis of α-ketoamides. Org Biomol Chem. 2019.