Development of a titanium dioxide-assisted preconcentration/on-site vapor-generation chip hyphenated with inductively coupled plasma-mass spectrometry for online determination of mercuric ions in urine samples.

Author(s) Shih, T.T.; Chen, J.Y.; Luo, Y.T.; Lin, C.H.; Liu, Y.H.; Su, Y.A.; Chao, P.C.; Sun, Y.C.
Journal Anal Chim Acta
Date Published 2019 Jul 31
Abstract

In this study, a novel automatic analytical methodology using a titanium dioxide (TiO)-assisted preconcentration/on-site vapor-generation (VG) chip hyphenated with inductively coupled plasma-mass spectrometry (ICP-MS) for online determination of mercuric ions (Hg) was developed. Interestingly, the TiO nanoparticle (nano-TiO) coating on the channel surface acted not only as a sorbent for preconcentration but also as a catalyst for photocatalyst-assisted VG. Under optimum operation conditions, the developed method was validated by analyzing the certified reference material (CRM) Seronorm™ Trace Elements Urine L-2 (freeze-dried human urine). Based on the obtained results, the dramatic reduction of "hands-on" manipulation and the elimination of hazardous materials (e.g., sodium borohydride (NaBH) and stannous chloride (SnCl)) from the process enabled a simple and ultraclean procedure with an extremely low detection limit of 0.75 ng L for Hg in urine samples. To the best of our knowledge, this is the first study to report the direct exploitation of a nano-TiO-coated microfluidic device for online sample preconcentration and on-site VG prior to ICP-MS measurement.

DOI 10.1016/j.aca.2019.02.035
ISSN 1873-4324
Citation Shih T-, Chen J-, Luo Y-, Lin C-, Liu Y-, Su Y-, et al. Development of a titanium dioxide-assisted preconcentration/on-site vapor-generation chip hyphenated with inductively coupled plasma-mass spectrometry for online determination of mercuric ions in urine samples. Anal Chim Acta. 2019;1063:82-90.

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