Development of upconversion nanoparticle-conjugated indium phosphide quantum dot for matrix metalloproteinase-2 cancer transformation sensing.

Author(s) Chan, M.H.; Lai, C.Y.; Chan, Y.C.; Hsiao, M.; Chung, R.J.; Chen, X.; Liu, R.S.
Journal Nanomedicine (Lond)
Date Published 2019 Jul 15

Matrix metalloproteinase-2 (MMP2) plays an important role in extracellular matrix remodeling, that is, it increases significantly during cancer progression. In this regard, MMP2 monitoring is important. A well-designed MMP2-sensitive polypeptide chain was used to link indium phosphide quantum dots (InP QDs) with upconversion nanoparticles (UCNPs) to form a nanocomposite that was utilized as biosensor. We produced a biosensor that can be recognized by MMP2 and determined the presence or absence of MMP2 in cells by identifying difference in fluorescence wavelength. The InP QDs modified the arginylglycylaspartic acid molecules as targeting ligand based on chitosan. The MMP2-based biosensor, named UCNP-p@InP-cRGD, is sensitive and can be applied for biosensing probes.

DOI 10.2217/nnm-2018-0524
ISSN 1748-6963
Citation Nanomedicine (Lond). 2019.

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