Direct Assembly of Polysubstituted Propiolamidinates via Palladium-Catalyzed Multicomponent Reaction of Isocyanides.

Author(s) Li, M.; Fang, S.; Zheng, J.; Jiang, H.; Wu, W.
Journal Org Lett
Date Published 2019 Oct 09

A straightforward approach for the assembly of different polysubstituted propiolamidnates via palladium-catalyzed multicomponent reaction of isocyanides, haloalkynes, and amines has been reported in which the C(sp)-C(sp) and C(sp)═N bonds were constructed in one pot. This reaction featured in high efficiency, excellent chemoselectivity, and good functional group compatibility. The synthetic utility of this method was also demonstrated.

DOI 10.1021/acs.orglett.9b03201
ISSN 1523-7052
Citation Org Lett. 2019.