Author(s) Sidorova, Y.S.; Zorin, S.N.; Petrov, N.A.; Shumakova, A.A.; Frolova, Y.V.; Mazo, V.K.
Journal Bull Exp Biol Med
Date Published 2020 Apr 04
Abstract

The effects of vanadium complex with enzymatic hydrolysate of soy protein (V-EHSPI) were studied in male Wistar rats with induced disorders of carbohydrate and lipid metabolism. The content of vanadium (IV) in the studied complex was 15.8 mg/g dry product. High-lipid high-carbohydrate diet was used to induce disorders of lipid and carbohydrate metabolism. Addition of vanadium in three different doses to the diet over 100-day experiment reduced body weight gain and the levels of glucose, insulin, leptin, and triglycerides. V-EHSPI produced beneficial effects on carbohydrate and lipid metabolism even in a dose 5 μg/kg body weight/day (calculated from the mean food consumption over the entire treatment period). Significant inhibition of growth and changes in the weight of organs in animals treated with V-EHSPI attested to toxicity of vanadium in the studied dose range.

DOI 10.1007/s10517-020-04769-x
ISSN 1573-8221
Citation Bull Exp Biol Med. 2020.

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