Effect of Vanadium Complex with Enzymatic Hydrolysate of Soy Protein on Carbohydrate and Lipid Metabolism Disorders in Male Wistar Rats.

Author(s) Sidorova, Y.S.; Zorin, S.N.; Petrov, N.A.; Shumakova, A.A.; Frolova, Y.V.; Mazo, V.K.
Journal Bull Exp Biol Med
Date Published 2020 Apr 04
Abstract

The effects of vanadium complex with enzymatic hydrolysate of soy protein (V-EHSPI) were studied in male Wistar rats with induced disorders of carbohydrate and lipid metabolism. The content of vanadium (IV) in the studied complex was 15.8 mg/g dry product. High-lipid high-carbohydrate diet was used to induce disorders of lipid and carbohydrate metabolism. Addition of vanadium in three different doses to the diet over 100-day experiment reduced body weight gain and the levels of glucose, insulin, leptin, and triglycerides. V-EHSPI produced beneficial effects on carbohydrate and lipid metabolism even in a dose 5 μg/kg body weight/day (calculated from the mean food consumption over the entire treatment period). Significant inhibition of growth and changes in the weight of organs in animals treated with V-EHSPI attested to toxicity of vanadium in the studied dose range.

DOI 10.1007/s10517-020-04769-x
ISSN 1573-8221
Citation Sidorova YS, Zorin SN, Petrov NA, Shumakova AA, Frolova YV, Mazo VK. Effect of Vanadium Complex with Enzymatic Hydrolysate of Soy Protein on Carbohydrate and Lipid Metabolism Disorders in Male Wistar Rats. Bull Exp Biol Med. 2020.

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