Effects of dodecacalcium hepta-aluminate content on the setting time, compressive strength, alkalinity, and cytocompatibility of tricalcium silicate cement.

Author(s) Choi, Y.; Bae, J.L.; Kim, H.J.; Yu, M.K.; Lee, K.W.; San Min, K.
Journal J Appl Oral Sci
Date Published 2019 Jan 07

OBJECTIVE: This study aimed to investigate the effects of dodecacalcium hepta-aluminate (C12A7) content on some physicochemical properties and cytocompatibility of tricalcium silicate (C3S) cement using human dental pulp cells (hDPCs).

MATERIAL AND METHODS: High purity C3S cement was manufactured by a solid phase method. C12A7 was mixed with the cement in proportions of 0, 5, 8, and 10 wt% (C12A7-0, -5, -8, and -10, respectively). Physicochemical properties including initial setting time, compressive strength, and alkalinity were evaluated. Cytocompatibility was assessed with cell viability tests and cell number counts. Statistical analysis was performed by using one-way analysis of variance (ANOVA) and Tukey's test (p<0.05).

RESULTS: The initial setting time of C3S-based cement was shorter in the presence of C12A7 (p<0.05). After 1 day, C12A7-5 showed significantly higher compressive strength than the other groups (p<0.05). After 7 days, the compressive strength of C12A7-5 was similar to that of C12A7-0, whereas other groups showed strength lower than C12A7-0. The pH values of all tested groups showed no significant differences after 1 day (p>0.05). The C12A7-5 group showed similar cell viability to the C12A7-0 group (p>0.05), while the other experimental groups showed lower values compared to C12A7-0 group (p<0.05). The number of cells grown on the C12A7-5 specimen was higher than that on C12A7-8 and -10 (p<0.05).

CONCLUSIONS: The addition of C12A7 to C3S cement at a proportion of 5% resulted in rapid initial setting time and higher compressive strength with no adverse effects on cytocompatibility.

DOI 10.1590/1678-7757-2018-0247
Keywords Aluminum Compounds; Biocompatible Materials; Calcium Compounds; Cell Survival; Cells, Cultured; Compressive Strength; Dental Cements; Dental Pulp Cavity; Humans; Materials Testing; Microscopy, Electron, Scanning; Particle Size; Reference Values; Reproducibility of Results; Silicates; Time Factors; X-Ray Diffraction
ISSN 1678-7765
Citation J Appl Oral Sci. 2019;27:e20180247.

Related Applications, Forms & Industries