Electroreductive 4-Pyridylation of Electron-deficient Alkenes with Assistance of Ni(acac)2.

Author(s) Zhang, S.; Li, L.; Li, X.; Zhang, J.; Xu, K.; Li, G.; Findlater, M.
Journal Org Lett
Date Published 2020 May 01
Abstract

An electroreductive 4-pyridylation of activated alkenes was developed in an undivided cell with the assistance of Ni(acac) (acac = acetylacetone). This novel protocol is compatible with a broad range of electron-poor alkenes, which are commonly regarded as challenging substrates in the previous conventional approaches. Moreover, a series of cyclic voltammetric experiments were conducted to reveal the unique role of Ni(acac) differentiating reduction process of reaction partners.

DOI 10.1021/acs.orglett.0c01014
ISSN 1523-7052
Citation Org Lett. 2020;22(9):35703575.

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