Enantioselective Catalyst Systems from Copper(II) Triflate and BINOL-Silanediol.

Author(s) Guan, Y.; Attard, J.W.; Visco, M.D.; Fisher, T.J.; Mattson, A.E.
Journal Chemistry
Date Published 2018 Mar 25
Abstract

Silanediol and copper catalysis are merged, for the first time, to create an enhanced Lewis acid catalyst system for enantioselective heterocycle functionalization. The promise of this silanediol and copper catalyst combination is demonstrated in the enantioselective addition of indoles to alkylidene malonates to give rise to the desirable adducts in excellent yield and high enantiomeric excess. From these studies, 1,1'-bi-2-naphthol (BINOL)-based silanediols emerge as one-of-a-kind cocatalysts. Their potential role in the reaction pathway is also discussed.

DOI 10.1002/chem.201801304
ISSN 1521-3765
Citation Guan Y, Attard JW, Visco MD, Fisher TJ, Mattson AE. Enantioselective Catalyst Systems from Copper(II) Triflate and BINOL-Silanediol. Chemistry. 2018.

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