Enantioselective Three-Component Assembly of β'-Aryl Enones Using a Rhodium-Catalyzed Alkyne Hydroacylation/Aryl Boronic Acid Conjugate Addition Sequence.

Author(s) Gao, M.; Willis, M.C.
Journal Org Lett
Date Published 2017 May 19
Abstract

Rhodium-catalyzed alkyne hydroacylation using alkyl β-S-aldehydes, enantioselective rhodium-catalyzed aryl boronic acid conjugate addition, and sulfide elimination are combined in sequence to provide β'-aryl enones. The reaction sequence is efficient and delivers highly functionalized products with excellent levels of enantiocontrol. Good variation of the three reaction components is demonstrated. The sequence corresponds to the formal regio- and enantioselective monoconjugate addition of aryl boronic acids to dienones.

DOI 10.1021/acs.orglett.7b01087
ISSN 1523-7052
Citation Gao M, Willis MC. Enantioselective Three-Component Assembly of β'-Aryl Enones Using a Rhodium-Catalyzed Alkyne Hydroacylation/Aryl Boronic Acid Conjugate Addition Sequence. Org Lett. 2017;19(10):2734-2737.

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