Facile meltPEGylation of flame-made luminescent Tb-doped yttrium oxide particles: hemocompatibility, cellular uptake and comparison to silica.

Author(s) Keevend, K.; Panzarasa, G.; Starsich, F.H.L.; Zeltner, M.; Spyrogianni, A.; Tsolaki, E.; Fortunato, G.; Pratsinis, S.E.; Bertazzo, S.; Herrmann, I.K.
Journal Chem Commun (Camb)
Date Published 2018 Mar 02

Flame aerosol technology is a versatile method for scalable synthesis of nanoparticles. Since particles are produced and collected in a dry state, dispersibility and further functionalization could pose hurdles to their biomedical use. We report on a one-pot, scalable and robust procedure for the PEGylation of flame-made yttria and silica nanoparticles. We demonstrate improved colloidal stability, attenuated activation of blood coagulation and decreased uptake into phagocytic cells, all of which pave the way for facilitated biomedical use of flame-made oxide nanoparticles.

DOI 10.1039/c7cc09402g
ISSN 1364-548X
Citation Chem Commun (Camb). 2018.

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