Green synthesis of highly dispersed ytterbium and thulium co-doped sodium yttrium fluoride microphosphors for in situ light upconversion from near-infrared to blue in animals.

Author(s) Pu, Y.; Lin, L.; Wang, D.; Wang, J.X.; Qian, J.; Chen, J.F.
Journal J Colloid Interface Sci
Date Published 2018 Feb 01
Abstract

We report a simple, low cost and environmentally friendly method to prepare NaYF:Yb, Tmupconversion microphosphors (UCMPs) by thermal decomposition of rare earth-trifluoroacetate precursors using paraffin as the high boiling non-coordinating solvent. The UCMPs exhibited cubic phase with defined shape and bright upconversion luminescence. After coating with amphiphilic polymers of phospholipid-polyethylene glycol, the NaYF:Yb, TmUCMPs were highly dispersed in aqueous solutions and exhibited low cytotoxicity. Furthermore, we explored the use of the micro-injected micro-sized NaYF:Yb, Tmparticles for converting of near infrared into blue light in mice brain. The in vivo macroscopic upconversion luminescence imaging results showed that UCMPs located at 1mm depth in the brain could be clearly distinguished. Microscopic upconversion luminescence imaging of the brain sections in vitro revealed that the UCMPs embedded at the particular location in brain tissues of mice were stable without significant diffusion in two weeks.

DOI 10.1016/j.jcis.2017.10.017
ISSN 1095-7103
Citation Pu Y, Lin L, Wang D, Wang J-, Qian J, Chen J-. Green synthesis of highly dispersed ytterbium and thulium co-doped sodium yttrium fluoride microphosphors for in situ light upconversion from near-infrared to blue in animals. J Colloid Interface Sci. 2018;511:243-250.

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