Grignard Reagents on a Tab: Direct Magnesium Insertion under Flow Conditions.

Author(s) Huck, L.; de la Hoz, A.; Díaz-Ortiz, A.; Alcázar, J.
Journal Org Lett
Date Published 2017 Jun 28
Abstract

An on-demand preparation of organomagnesium reagents is presented using a new flow protocol. The risks associated with the activation of magnesium are circumvented by a new on-column initiation procedure. Required amounts of solutions with a precise titration were obtained. Telescoped flow or batch reactions allow access to a diverse set of functional groups.

DOI 10.1021/acs.orglett.7b01590
ISSN 1523-7052
Citation Huck L, de la Hoz A, Díaz-Ortiz A, Alcázar J. Grignard Reagents on a Tab: Direct Magnesium Insertion under Flow Conditions. Org Lett. 2017.

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