Hafnium(IV) triflate as a potent catalyst for selective 1-O-deacetylation of peracetylated saccharides.

Author(s) Wang, R.; Chen, J.Z.; Zheng, X.A.; Kong, R.; Gong, S.S.; Sun, Q.
Journal Carbohydr Res
Date Published 2018 Jan 02

An efficient method for selective anomeric deacetylation of peracetylated mono-, di-, and trisaccharides has been developed by using 2 mol% Hf(OTf)4 as catalyst in acetonitrile. Employment of ultrasonic irradiation could significantly accelerate the reaction rate. Mechanistic study confirmed the hydrolysis nature of this reaction, and NMR experimental data suggested that multiple peracetylated saccharide molecules may ligate to Hf(IV) cation primarily via the anomeric acetate to promote its specific hydrolysis.

DOI 10.1016/j.carres.2017.11.015
ISSN 1873-426X
Citation Carbohydr Res. 2018;455:114118.

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