High-Precision Photothermal Ablation using Biocompatible Palladium Nanoparticles and Laser Scanning Microscopy.

Author(s) Ruiz, B.Rubio; Perez-Lopez, A.; Bray, T.; Lee, M.; Serrels, A.; Prieto, M.; Arruebo, M.; Carragher, N.O.; Sebastian, V.; Unciti-Broceta, A.
Journal ACS Appl Mater Interfaces
Date Published 2018 Jan 10

Herein we report a straightforward method for the scalable preparation of Pd nanoparticles (Pd-NPs) with reduced inherent cytotoxicity and high photothermal conversion capacity. These Pd-NPs are rapidly taken up by cells and able to kill labelled cancer cells upon short exposure to near infrared (NIR) light. Following cell treatment with Pd-NPs, ablated areas were patterned with high precision by laser scanning microscopy, allowing to perform cell migration assays with unprecedented accuracy. Using coherent Raman microscopy, cells containing Pd-NPs were simultaneously ablated and imaged. This novel methodology was combined with intravital imaging to mediate micro-ablation of cancerous tissue in tumour xenografts in mice.

DOI 10.1021/acsami.7b17282
ISSN 1944-8252
Citation ACS Appl Mater Interfaces. 2018.

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