Highly isoselective ring-opening polymerization of rac-O-carboxyanhydrides using a zinc alkoxide initiator.

Author(s) Cui, Y.; Jiang, J.; Pan, X.; Wu, J.
Journal Chem Commun (Camb)
Date Published 2019 Oct 24
Abstract

The stereoselective ring-opening polymerization (ROP) of O-carboxyanhydrides (OCAs) remains a major challenge due to the easy epimerization of monomers. In this work, using a zinc alkoxide initiator, highly efficient ROP of enantiopure 5-methyl-1,3-dioxolane-2,4-dione (LacOCA), 5-benzyl-1,3-dioxolane-2,4-dione (PheOCA), and 5-(4-(benzyloxy)benzyl)-1,3-dioxolane-2,4-dione (Try(Bn)OCA) was achieved without obvious epimerization. Moreover, highly isoselective ROP of rac-LacOCA, rac-PheOCA, and rac-Try(Bn)OCA was successful with the highest isoselectivity of Pm = 0.97 at -70 °C.

DOI 10.1039/c9cc06108h
ISSN 1364-548X
Citation Cui Y, Jiang J, Pan X, Wu J. Highly isoselective ring-opening polymerization of rac-O-carboxyanhydrides using a zinc alkoxide initiator. Chem Commun (Camb). 2019;55(86):12948-12951.

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