Hydride Transfer Enables the Nickel-catalyzed ipso-Borylation and Silylation of Aldehydes Watchara Srimontree, Lin Guo and Magnus Rueping.

Author(s) Srimontree, W.; Guo, L.; Rueping, M.
Journal Chemistry
Date Published 2019 Oct 29

Nickel-catalyzed ipso-borylations and silylations of aldehydes are described for the first time. The new functional group interconversion protocol is characterized by its scalability, functional group tolerance and wide substrate scope, including examples of late-stage functionalization of complex molecules. The key for the successful reaction outcome is the use of a ketone as hydride acceptor which intercepts the nickel hydride to undergo a reductive pathway, thus allowing formation of the desired C-B and C-Si bonds.

DOI 10.1002/chem.201904842
ISSN 1521-3765
Citation Chemistry. 2019.

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