Indium-catalysed amide allylation of α-iminoamide: highly enantioselective synthesis of amide functionalised α-methylene-γ-butyrolactams.
Title | Indium-catalysed amide allylation of α-iminoamide: highly enantioselective synthesis of amide functionalised α-methylene-γ-butyrolactams. |
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Authors | Sengoku, T.; Kokubo, K.; Sakamoto, M.; Takahashi, M.; Yoda, H. |
Journal | Org Biomol Chem |
DOI | 10.1039/c6ob02506d |
Abstract |
A highly enantioselective amide allylation of α-iminoamides has been achieved using catalytic amounts of InCl3, ZnCl2 and a BINOL derivative. This reaction allowed facile access to a variety of amide functionalised α-methylene-γ-butyrolactams in excellent yields with high enantioselectivities. |